PKIA - cAMP-dependent protein kinase inhibitor alpha Gene

Homo sapiens

Also known as PRKACN1

Gene ID: 5569 | Gene type: protein coding

About PKIA

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:78,516,340-78,605,267 (from NCBI)

This gene has 3 transcripts (splice variants), 127 orthologues and 2 paralogues. Biased expression in heart (RPKM 28.1), brain (RPKM 26.1) and 11 other tissues.

Summary

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

PKIA Products(2)

mRNA	Protein	Name
NM_006823.4	NP_006814.1	cAMP-dependent protein kinase inhibitor alpha
NM_181839.3	NP_862822.1	cAMP-dependent protein kinase inhibitor alpha

PKIA Protein Structure

PKI

0
76 a.a.

Protein Preferred Names

Protein Names

cAMP-dependent protein kinase inhibitor alpha

PKI-alpha

Related Diseases

Diseases

Alias

Chromosome 8q21.11 Deletion Syndrome

8q21.11 Microdeletion Syndrome	Del(8)(Q21.11)
Deletion 8q21.11	Monosomy 8q21.11

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10598	PKIA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PKIA	RGD	RGD:621021
Bos taurus	PKIA	VGNC	VGNC:32940
Felis catus	PKIA	VGNC	VGNC:81705
Canis familiaris	PKIA	VGNC	VGNC:44607
Mus musculus	PKIA	MGD	MGI:104747