PKIA - cAMP-dependent protein kinase inhibitor alpha Gene

Also Known as PRKACN1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5569

About PKIA

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:78,516,340-78,605,267 (from NCBI)

This gene has 3 transcripts (splice variants), 127 orthologues and 2 paralogues. Biased expression in heart (RPKM 28.1), brain (RPKM 26.1) and 11 other tissues.

Summary

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

PKIA Products (2)

mRNA Protein Name
NM_006823.4 NP_006814.1 cAMP-dependent protein kinase inhibitor alpha
NM_181839.3 NP_862822.1 cAMP-dependent protein kinase inhibitor alpha

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cAMP-dependent protein kinase inhibitor activity IDA
IDA: Inferred from direct assay
7905001 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20485264 GOA
enables protein kinase A catalytic subunit binding IPI
IPI: Inferred from physical interaction
21812984 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of cAMP-dependent protein kinase activity IDA
IDA: Inferred from direct assay
7905001 GOA
involved in negative regulation of cAMP/PKA signal transduction IDA
IDA: Inferred from direct assay
21812984 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKIA Protein Structure

PKI

PKI: cAMP-dependent protein kinase inhibitor (2 - 75)

  • 0
  • 76 a.a.
Protein Preferred Names Protein Names

cAMP-dependent protein kinase inhibitor alpha

  • PKI-alpha

PKIA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
PKIA P61925 CRM1 Saccharomyces cerevisiae P30822
Pull Down
20485264
Cross
PKIA P61925 CRM1 Saccharomyces cerevisiae P30822
FRET
20485264
Cross
PKIA P61925 Xpo1 Mus musculus Q6P5F9
GMS
20972448
Cross
PKIA P61925 Xpo1 Mus musculus Q6P5F9
FPS
20972448
Intra
PKIA P61925 PRKACB Homo sapiens P22694
Y2H Array
32296183
Intra
PKIA P61925 PRKACB Homo sapiens P22694
Y2H Prey Pooling
32296183
Intra
PKIA P61925 MRNIP Homo sapiens Q6NTE8
Validated Y2H
32296183
Intra
PKIA P61925 MRNIP Homo sapiens Q6NTE8
Y2H Prey Pooling
32296183
Intra
PKIA P61925 MRNIP Homo sapiens Q6NTE8
Y2H Array
32296183
Intra
PKIA P61925 DYNLL1 Homo sapiens P63167
Y2H Prey Pooling
32296183
Intra
PKIA P61925 DYNLL1 Homo sapiens P63167
Y2H Array
32296183
Intra
PKIA P61925 DYNLL1 Homo sapiens P63167
Validated Y2H
32296183
Intra
PKIA P61925 XPO1 Homo sapiens O14980
FRET
20485264
Intra
PKIA P61925 CASP6 Homo sapiens P55212
Y2H Array
32296183
Intra
PKIA P61925 CASP6 Homo sapiens P55212
Y2H Prey Pooling
32296183
Intra
PKIA P61925 PRC1 Homo sapiens O43663
Y2H Prey Pooling
32296183
Intra
PKIA P61925 PRC1 Homo sapiens O43663
Y2H Array
32296183
Intra
PKIA P61925 DYNLL2 Homo sapiens Q96FJ2
Validated Y2H
32296183
Intra
PKIA P61925 DYNLL2 Homo sapiens Q96FJ2
Y2H Array
32296183
Intra
PKIA P61925 DYNLL2 Homo sapiens Q96FJ2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 8q21.11 Deletion Syndrome

  • 8q21.11 Microdeletion Syndrome

  • Del(8)(Q21.11)

  • Deletion 8q21.11

  • Monosomy 8q21.11
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10598 PKIA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PKIA RGD RGD:621021
Bos taurus PKIA VGNC VGNC:32940
Felis catus PKIA VGNC VGNC:81705
Canis familiaris PKIA VGNC VGNC:44607
Mus musculus PKIA MGD MGI:104747
Others PKIA NCBI