LONRF2 - LON peptidase N-terminal domain and ring finger 2 Gene

Also Known as RNF192

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 164832

About LONRF2

This gene has 2 transcripts (splice variants), 204 orthologues and 2 paralogues. Biased expression in adrenal (RPKM 18.3), brain (RPKM 16.1) and 10 other tissues.

Summary

Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]

LONRF2 Products (2)

mRNA Protein Name
NM_001371783.1 NP_001358712.1 LON peptidase N-terminal domain and RING finger protein 2 isoform 2
NM_198461.4 NP_940863.3 LON peptidase N-terminal domain and RING finger protein 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LONRF2 Protein Structure

TPR_11

TPR_11: TPR repeat (203 - 262)

zf-RING_2

zf-RING_2: Ring finger domain (448 - 487)

LON_substr_bdg

LON_substr_bdg: ATP-dependent protease La (LON) substrate-binding domain (538 - 733)

  • 0
  • 200
  • 400
  • 600
  • 754 a.a.
Protein Preferred Names Protein Names

LON peptidase N-terminal domain and RING finger protein 2

  • RING finger protein 192

LONRF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LONRF2 Q1L5Z9 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
LONRF2 Q1L5Z9 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
LONRF2 Q1L5Z9 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
LONRF2 Q1L5Z9 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
LONRF2 Q1L5Z9 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
LONRF2 Q1L5Z9 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
LONRF2 Q1L5Z9 CCT5 Homo sapiens P48643
Y2H Array
32814053
Intra
LONRF2 Q1L5Z9 CCT5 Homo sapiens P48643
Validated Y2H
32814053
Intra
LONRF2 Q1L5Z9 CCT5 Homo sapiens P48643
Y2H Pooling
32814053
Intra
LONRF2 Q1L5Z9 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
LONRF2 Q1L5Z9 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
LONRF2 Q1L5Z9 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
LONRF2 Q1L5Z9 HTRA2 Homo sapiens O43464
Y2H Array
32814053
Intra
LONRF2 Q1L5Z9 HTRA2 Homo sapiens O43464
Y2H Pooling
32814053
Intra
LONRF2 Q1L5Z9 HTRA2 Homo sapiens O43464
Validated Y2H
32814053
Intra
LONRF2 Q1L5Z9 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
LONRF2 Q1L5Z9 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
LONRF2 Q1L5Z9 GFAP Homo sapiens P14136
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 15b

  • IMD15B

  • Immunodeficiency, Type 15b
Childhood Germ Cell Cancer

  • Pediatric Germ Cell Tumor

  • Paediatric Germ Cell Cancer

  • Paediatric Germ Cell Neoplasm

  • Pediatric Germ Cell Cancer

  • Pediatric Germ Cell Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07736 LONRF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LONRF2 RGD RGD:1562137
Macaca mulatta LONRF2 VGNC VGNC:74348
Mus musculus LONRF2 MGD MGI:1920209
Canis familiaris LONRF2 VGNC VGNC:42735
Felis catus LONRF2 VGNC VGNC:63257
Others LONRF2 NCBI