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Cat. No.: HY-125194

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NWL-117

NWL-117 is a brain-penetrant and highly selective Caspase-6 (Casp6) inhibitor with an IC₅₀ value of 192 nM. NWL-117 is promising for research of neurodegenerative diseases, particularly Alzheimer's disease and Huntington's disease .

For research use only. We do not sell to patients.

CAS No.: 2267318-43-2
Formula: C₂₉H₄₂N₄O₁₁S
Molecular Weight:654.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

NWL-117 Chemical Structure

CAS No.: 2267318-43-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Caspase Isoforms :

Chemical Information

CAS No. 2267318-43-2
Molecular Weight 654.73
Formula C₂₉H₄₂N₄O₁₁S
SMILES

O=C(O)[C@@H](/C=C/S(=O)(C)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pakavathkumar P, et al. Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice. Mol Neurodegener. 2017 Feb 28;12(1):22. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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