LOXL4 - lysyl oxidase like 4 Gene

Also Known as LOXC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84171

About LOXL4

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:98,247,690-98,268,194 (from NCBI)

This gene has 1 transcript (splice variant), 288 orthologues and 15 paralogues. Broad expression in thyroid (RPKM 4.0), testis (RPKM 3.7) and 22 other tissues.

Summary

This gene encodes a member of the Lysyl Oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

LOXL4 Products (1)

mRNA Protein Name
NM_032211.7 NP_115587.6 lysyl oxidase homolog 4 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein-lysine 6-oxidase activity IDA
IDA: Inferred from direct assay
14551188 GOA
Cellular Component GO Annotation Evidence References Source
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LOXL4 Protein Structure

SRCR

SRCR: Scavenger receptor cysteine-rich domain (39 - 132)

SRCR

SRCR: Scavenger receptor cysteine-rich domain (175 - 286)

SRCR

SRCR: Scavenger receptor cysteine-rich domain (315 - 411)

SRCR

SRCR: Scavenger receptor cysteine-rich domain (425 - 528)

Lysyl_oxidase

Lysyl_oxidase: Lysyl oxidase (533 - 735)

  • 0
  • 200
  • 400
  • 600
  • 756 a.a.
Protein Preferred Names Protein Names

lysyl oxidase homolog 4

  • lysyl oxidase related C

LOXL4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LOXL4 Q96JB6 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
LOXL4 Q96JB6 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
LOXL4 Q96JB6 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
LOXL4 Q96JB6 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra
LOXL4 Q96JB6 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra
LOXL4 Q96JB6 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra
LOXL4 Q96JB6 CCT6B Homo sapiens Q92526
Anti Tag CoIP
33961781
Intra
LOXL4 Q96JB6 CCT6B Homo sapiens Q92526
Anti Tag CoIP
28514442
Intra
LOXL4 Q96JB6 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
LOXL4 Q96JB6 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
LOXL4 Q96JB6 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
LOXL4 Q96JB6 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
LOXL4 Q96JB6 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
LOXL4 Q96JB6 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
LOXL4 Q96JB6 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
LOXL4 Q96JB6 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
LOXL4 Q96JB6 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
LOXL4 Q96JB6 TRIP13 Homo sapiens Q15645
Y2H Array
25416956
Intra
LOXL4 Q96JB6 TRIP13 Homo sapiens Q15645
Y2H Pooling
19060904
Intra
LOXL4 Q96JB6 TRIP13 Homo sapiens Q15645
Validated Y2H
25416956
Intra
LOXL4 Q96JB6 TRIP13 Homo sapiens Q15645
Y2H Array
19060904
Intra
LOXL4 Q96JB6 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
LOXL4 Q96JB6 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
LOXL4 Q96JB6 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
LOXL4 Q96JB6 KDM1A Homo sapiens O60341
Anti Tag CoIP
23455924
Intra
LOXL4 Q96JB6 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
LOXL4 Q96JB6 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
LOXL4 Q96JB6 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
LOXL4 Q96JB6 PRMT6 Homo sapiens Q96LA8
Y2H
23455924
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pelvic Organ Prolapse

  • Rectal Prolapse

  • Pelvic Organ Prolapse, Susceptibility To, 1

  • Pelvic Organ Prolapse, Susceptibility To

  • Prolapse Of Vagina And Rectum

  • Vaginal Prolapse

  • Pelvic Organ Prolapse 1

  • Procidentia, Rectum

  • Prolapse Of Rectal Mucosa

  • Procidentia Of Rectum

  • Rectal Mucosa Prolapse

  • Rectum Prolapse

  • Procidentia Rectum

  • Rp - [Rectal Prolapse]

  • Male Proctocele

  • Male Rectocele

  • Proctoptosis

  • Female Genital Prolapse

  • Female Prolapse

  • Incompetence Of Pelvic Fundus

  • Relaxation Of Perineum

  • Deficiency Of Perineum
Squamous Cell Carcinoma, Head And Neck

  • Squamous Cell Carcinoma Of The Head And Neck

  • HNSCC

  • Head And Neck Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Lip

  • Squamous Cell Carcinoma, Head And Neck, Somatic

  • Carcinoma Of The Head And Neck

  • Squamous Cell Carcinomas Of Head And Neck

  • Scchn

  • Squamous Cell Carcinoma Of The Hypopharynx

  • Squamous Cell Carcinoma Of The Oropharynx

  • Squamous Cell Carcinoma Of Salivary Glands

  • Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

  • Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

  • Squamous Cell Carcinoma Of The Oral Cavity

  • Squamous Cell Carcinoma Of The Lip

  • Carcinoma, Squamous Cell Of Head And Neck

  • Lip Squamous Cell Carcinoma

  • Carcinoma, Squamous Cell, Head And Neck

  • Salivary Gland Squamous Cell Carcinoma

  • Cancer Of Head And Neck

  • Squamous Cell Carcinoma Of Oropharynx Nos
Phacogenic Glaucoma
Urofacial Syndrome 1

  • Urofacial Syndrome

  • Ochoa Syndrome

  • Hydronephrosis With Peculiar Facial Expression

  • Ufs

  • Inverted Smile And Occult Neuropathic Bladder

  • Partial Facial Palsy With Urinary Abnormalities

  • UFS1

  • Urofacial Ochoa'S Syndrome

  • Urofacial Syndrome Type 1

  • Facial Palsy, Partial, With Urinary Abnormalities

  • Hydronephrosis-Inverted Smile

  • Inverted Smile-Neurogenic Bladder

  • Hydronephrosis-Inverted Smile Syndrome

  • Inverted Smile-Neurogenic Bladder Syndrome

  • Partial Facial Palsy Partial With Urinary Abnormalities

  • Urologic Diseases
Scoliosis
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-170538 SNT-5382 Inhibitor 99.96% Unkown
HY-151499A PXS-6302 hydrochloride Inhibitor 99.57% Unkown
HY-151498A PXS-4787 hydrochloride Inhibitor 99.71% Unkown
HY-151498 PXS-4787 Inhibitor / Unkown
HY-151499 PXS-6302 Inhibitor / Unkown
HY-RS07744 LOXL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19454 Loxl4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25947 Loxl4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LOXL4 MGD MGI:1914823
Canis familiaris LOXL4 VGNC VGNC:42741
Felis catus LOXL4 VGNC VGNC:63260
Bos taurus LOXL4 VGNC VGNC:55958
Rattus norvegicus LOXL4 RGD RGD:1308588
Others LOXL4 NCBI