LOXL4 - lysyl oxidase like 4 Gene

Homo sapiens

Also known as LOXC

Gene ID: 84171 | Gene type: protein coding

About LOXL4

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:98,247,690-98,268,194 (from NCBI)

This gene has 1 transcript (splice variant), 288 orthologues and 15 paralogues. Broad expression in thyroid (RPKM 4.0), testis (RPKM 3.7) and 22 other tissues.

Summary

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

LOXL4 Products(1)

mRNA	Protein	Name
NM_032211.7	NP_115587.6	lysyl oxidase homolog 4 precursor

LOXL4 Protein Structure

SRCR

Lysyl_oxidase

0
200
400
600
756 a.a.

Protein Preferred Names

Protein Names

lysyl oxidase homolog 4

lysyl oxidase related C

Related Diseases

Diseases

Alias

Pelvic Organ Prolapse

Rectal Prolapse	Pelvic Organ Prolapse, Susceptibility To, 1
Pelvic Organ Prolapse, Susceptibility To	Prolapse Of Vagina And Rectum
Vaginal Prolapse	Pelvic Organ Prolapse 1
Procidentia, Rectum	Prolapse Of Rectal Mucosa
Procidentia Of Rectum	Rectal Mucosa Prolapse
Rectum Prolapse	Procidentia Rectum
Rp - [Rectal Prolapse]	Male Proctocele
Male Rectocele	Proctoptosis
Female Genital Prolapse	Female Prolapse
Incompetence Of Pelvic Fundus	Relaxation Of Perineum
Deficiency Of Perineum

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lip
Squamous Cell Carcinoma, Head And Neck, Somatic	Carcinoma Of The Head And Neck
Squamous Cell Carcinomas Of Head And Neck	Scchn
Squamous Cell Carcinoma Of The Hypopharynx	Squamous Cell Carcinoma Of The Oropharynx
Squamous Cell Carcinoma Of Salivary Glands	Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses
Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses	Squamous Cell Carcinoma Of The Oral Cavity
Squamous Cell Carcinoma Of The Lip	Carcinoma, Squamous Cell Of Head And Neck
Lip Squamous Cell Carcinoma	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

Phacogenic Glaucoma

Urofacial Syndrome 1

Urofacial Syndrome	Ochoa Syndrome
Hydronephrosis With Peculiar Facial Expression	Ufs
Inverted Smile And Occult Neuropathic Bladder	Partial Facial Palsy With Urinary Abnormalities
UFS1	Urofacial Ochoa'S Syndrome
Urofacial Syndrome Type 1	Facial Palsy, Partial, With Urinary Abnormalities
Hydronephrosis-Inverted Smile	Inverted Smile-Neurogenic Bladder
Hydronephrosis-Inverted Smile Syndrome	Inverted Smile-Neurogenic Bladder Syndrome
Partial Facial Palsy Partial With Urinary Abnormalities	Urologic Diseases

Scoliosis

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151499A	PXS-6302 hydrochloride	Inhibitor	99.83%	Unkown
HY-151499	PXS-6302	Inhibitor	/	Unkown
HY-151498	PXS-4787	Inhibitor	/	Unkown
HY-RS07744	LOXL4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LOXL4	MGD	MGI:1914823
Canis familiaris	LOXL4	VGNC	VGNC:42741
Felis catus	LOXL4	VGNC	VGNC:63260
Bos taurus	LOXL4	VGNC	VGNC:55958
Rattus norvegicus	LOXL4	RGD	RGD:1308588
Others	LOXL4	NCBI

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