PXS-4787 hydrochloride
Based on 1 Customer Validation
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 hydrochloride inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively. PXS-4787 hydrochloride reduces deposition and crosslinking of collagen I secreted by human fibroblasts.
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- Reinheit : 99.71%
- CAS. Nr.: 2409964-40-3
- Formel: C10H13ClFNO2S
- Molecular Weight:265.73
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4)[1]
Chemical Information
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CAS. Nr. 2409964-40-3
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Appearance Solid
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Molecular Weight 265.73
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Formel C10H13ClFNO2S
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Color White to off-white
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SMILES
NC/C=C(CS(=O)(C1=CC=CC=C1)=O)\F.Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (376.32 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7632 mL | 18.8161 mL | 37.6322 mL | 94.0805 mL |
| 5 mM | 0.7526 mL | 3.7632 mL | 7.5264 mL | 18.8161 mL | |
| 10 mM | 0.3763 mL | 1.8816 mL | 3.7632 mL | 9.4080 mL | |
| 15 mM | 0.2509 mL | 1.2544 mL | 2.5088 mL | 6.2720 mL | |
| 20 mM | 0.1882 mL | 0.9408 mL | 1.8816 mL | 4.7040 mL | |
| 25 mM | 0.1505 mL | 0.7526 mL | 1.5053 mL | 3.7632 mL | |
| 30 mM | 0.1254 mL | 0.6272 mL | 1.2544 mL | 3.1360 mL | |
| 40 mM | 0.0941 mL | 0.4704 mL | 0.9408 mL | 2.3520 mL | |
| 50 mM | 0.0753 mL | 0.3763 mL | 0.7526 mL | 1.8816 mL | |
| 60 mM | 0.0627 mL | 0.3136 mL | 0.6272 mL | 1.5680 mL | |
| 80 mM | 0.0470 mL | 0.2352 mL | 0.4704 mL | 1.1760 mL | |
| 100 mM | 0.0376 mL | 0.1882 mL | 0.3763 mL | 0.9408 mL |
PXS-4787 hydrochloride Related Classifications
HY-151498A Related Classifications
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