PXS-6302

Cat. No.: HY-151499: FAQs
Data Sheet Handling Instructions

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PXS-6302 is an irreversible lysyl oxidase inhibitor with IC₅₀s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance.

For research use only. We do not sell to patients.

PXS-6302 Chemical Structure

CAS No. : 2584947-54-4

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Other In-stock Forms of PXS-6302:

Other Forms of PXS-6302:

PXS-6302 hydrochloride In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4)^[1]

In Vitro

PXS-6302 demonstrates high permeability to across a monolayer of cells, such as Caco-2 or MDCKII cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PXS-6302 inhibits LOX, reduces crosslinking and improves scar appearance in porcine models of excisional and burn injury^[1].
PXS-6302 (1.5%, oil in water cream; 500 mg cream applied to 16 cm²; external application; once daily, for 28 days) reduces collagen deposition and cross-linkin in murine models of injury and fibrosis under topical application^[1].
PXS-6302 (0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm²; external application; once daily, for 12 weeks) also significantly improves scar appearance without reducing tissue strength in porcine injury models under topical application^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Porcine excision injury model (female Juvenile pigs, 18-20 kg)^[1]
Dosage:	0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm²
Administration:	External application; 1, 2 and 3 weeks post-injury; once dayly, for 12 weeks
Result:	Showed significantly higher scores for the 3% treated scars suggesting significant improvement in scar appearance.

Molecular Weight

265.25

Formula

C₁₀H₁₀F₃NO₂S

CAS No.

2584947-54-4

SMILES

NC/C=C(C(F)(S(=O)(C1=CC=CC=C1)=O)F)\F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (377.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7700 mL	18.8501 mL	37.7003 mL
5 mM	0.7540 mL	3.7700 mL	7.5401 mL
10 mM	0.3770 mL	1.8850 mL	3.7700 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (9.43 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 2.5 mg/mL (9.43 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13(1):5555. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7700 mL	18.8501 mL	37.7003 mL	94.2507 mL
	5 mM	0.7540 mL	3.7700 mL	7.5401 mL	18.8501 mL
	10 mM	0.3770 mL	1.8850 mL	3.7700 mL	9.4251 mL
	15 mM	0.2513 mL	1.2567 mL	2.5134 mL	6.2834 mL
	20 mM	0.1885 mL	0.9425 mL	1.8850 mL	4.7125 mL
	25 mM	0.1508 mL	0.7540 mL	1.5080 mL	3.7700 mL
	30 mM	0.1257 mL	0.6283 mL	1.2567 mL	3.1417 mL
	40 mM	0.0943 mL	0.4713 mL	0.9425 mL	2.3563 mL
	50 mM	0.0754 mL	0.3770 mL	0.7540 mL	1.8850 mL
	60 mM	0.0628 mL	0.3142 mL	0.6283 mL	1.5708 mL
	80 mM	0.0471 mL	0.2356 mL	0.4713 mL	1.1781 mL
	100 mM	0.0377 mL	0.1885 mL	0.3770 mL	0.9425 mL

PXS-6302 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PXS-63022584947-54-4PXS6302PXS 6302Monoamine OxidaseMAOskin treatmentpenetrating skincollagen depositionscar appearancescar tissuemurine models of injury and fibrosisporcine injury modelsInhibitorinhibitorinhibit

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