JADE3 - jade family PHD finger 3 Gene

Also Known as PHF16; JADE-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9767

About JADE3

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:46,912,301-47,061,242 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues and 8 paralogues. Broad expression in testis (RPKM 8.9), placenta (RPKM 7.4) and 25 other tissues.

Summary

This gene encodes a member of a family of large proteins containing PHD (plant homeo domain)-type zinc fingers. The encoded protein may be associated in a nuclear complex that functions in histone H4 acetylation. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2013]

JADE3 Products (2)

mRNA Protein Name
NM_001077445.3 NP_001070913.1 protein Jade-3
NM_014735.5 NP_055550.1 protein Jade-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of DNA biosynthetic process IDA
IDA: Inferred from direct assay
16387653 GOA
involved in regulation of DNA replication IDA
IDA: Inferred from direct assay
16387653 GOA
involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
16387653 GOA
Cellular Component GO Annotation Evidence References Source
part of histone acetyltransferase complex IDA
IDA: Inferred from direct assay
16387653 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
16387653 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JADE3 Protein Structure

EPL1

EPL1: Enhancer of polycomb-like (37 - 177)

PHD_2

PHD_2: PHD-finger (215 - 247)

zf-HC5HC2H_2

zf-HC5HC2H_2: PHD-zinc-finger like domain (254 - 365)

  • 0
  • 200
  • 400
  • 600
  • 823 a.a.
Protein Preferred Names Protein Names

protein Jade-3

  • PHD finger protein 16

JADE3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
JADE3 Q92613 MAGEA11 Homo sapiens P43364-2
Validated Y2H
25416956
Intra
JADE3 Q92613 MAGEA11 Homo sapiens P43364-2
Y2H Prey Pooling
25416956
Intra
JADE3 Q92613 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
Intra
JADE3 Q92613 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
Intra
JADE3 Q92613 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
Intra
JADE3 Q92613 MAGEA11 Homo sapiens P43364
Y2H Array
32296183
Intra
JADE3 Q92613 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
32296183
Intra
JADE3 Q92613 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
JADE3 Q92613 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
JADE3 Q92613 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07011 JADE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22581 Jade3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus JADE3 VGNC VGNC:62997
Macaca mulatta JADE3 VGNC VGNC:73640
Rattus norvegicus JADE3 RGD RGD:1563945
Canis familiaris JADE3 VGNC VGNC:42171
Bos taurus JADE3 VGNC VGNC:30360
Mus musculus JADE3 MGD MGI:2148019
Others JADE3 NCBI