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STAG1 - stromal antigen 1 Gene

Also Known as SA1; MRD47; SCC3A

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 10274

About STAG1

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:136,336,236-136,752,378 (from NCBI)

This gene has 10 transcripts (splice variants), 221 orthologues, 2 paralogues and is associated with 88 phenotypes. Ubiquitous expression in ovary (RPKM 10.7), endometrium (RPKM 9.9) and 25 other tissues.

Summary

This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]

STAG1 Products (1)

mRNA	Protein	Name
NM_005862.3	NP_005853.2	cohesin subunit SA-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	15855230	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	11590136	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in chromatin	IDA IDA: Inferred from direct assay	16682347	GOA
part of cohesin complex	IDA IDA: Inferred from direct assay	11590136	GOA
located in mitotic spindle pole	IDA IDA: Inferred from direct assay	11590136	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	11590136	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAG1 Protein Structure

STAG

0
200
400
600
800
1000
1200
1258 a.a.

Protein Preferred Names	Protein Names
cohesin subunit SA-1	SCC3 homolog 1

STAG1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	STAG1	Q8WVM7	STAG2	Homo sapiens	Q8N3U4	Anti Bait CoIP	29867216
Intra	STAG1	Q8WVM7	STAG2	Homo sapiens	Q8N3U4	Anti Tag CoIP	35271311
Intra	STAG1	Q8WVM7	STAG2	Homo sapiens	Q8N3U4	Crosslink	30021884
Intra	STAG1	Q8WVM7	PDS5A	Homo sapiens	Q29RF7	Anti Bait CoIP	17113138
Intra	STAG1	Q8WVM7	PDS5B	Homo sapiens	Q9NTI5	Anti Bait CoIP	29867216
Intra	STAG1	Q8WVM7	PDS5B	Homo sapiens	Q9NTI5	Anti Bait CoIP	17113138
Intra	STAG1	Q8WVM7	TERF1	Homo sapiens	P54274	Pull Down	17962804
Intra	STAG1	Q8WVM7	TERF1	Homo sapiens	P54274	Anti Tag CoIP	17962804
Intra	STAG1	Q8WVM7	TERF1	Homo sapiens	P54274	Anti Bait CoIP	17962804
Intra	STAG1	Q8WVM7	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	22885700
Intra	STAG1	Q8WVM7	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	15855230
Intra	STAG1	Q8WVM7	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	17962804
Intra	STAG1	Q8WVM7	SMC3	Homo sapiens	Q9UQE7	Anti Tag CoIP	35271311
Intra	STAG1	Q8WVM7	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	17112726
Intra	STAG1	Q8WVM7	SMC3	Homo sapiens	Q9UQE7	Pull Down	17962804
Intra	STAG1	Q8WVM7	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	29867216
Intra	STAG1	Q8WVM7	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	17113138

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 47	Mental Retardation, Autosomal Dominant 47 MRD47 Autosomal Dominant Intellectual Developmental Disorder 47 Autosomal Dominant Mental Retardation 47 Stag1-Related Intellectual Disability-Facial Dysmorphism-Gastroesophageal Reflux Syndrome
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Amelogenesis Imperfecta, Type If	Amelogenesis Imperfecta Type 1f AI1F Amelogenesis Imperfecta, Hypoplastic Type If Amelogenesis Imperfecta Type If Amelogenesis Imperfecta Hypoplastic Type If Amelogenesis Imperfecta 1f
Roberts-Sc Phocomelia Syndrome	Roberts Syndrome Sc Phocomelia Syndrome RBS Long Bone Deficiencies Associated With Cleft Lip-Palate Sc Pseudothalidomide Syndrome Appelt-Gerken-Lenz Syndrome Pseudothalidomide Syndrome Tetraphocomelia-Cleft Palate Syndrome Hypomelia Hypotrichosis Facial Hemangioma Syndrome Roberts Syndrome/Sc Phocomelia Roberts Tetraphocomelia Syndrome Sc Syndrome Sc Phocomelia Sc Disease Sc Hemoglobin Sc Disease
Atrial Septal Defect 1	ASD1 Atrial Heart Septal Defect 1 Asd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-P10931F	RAD21 (356–395), biotin labeled		/	Unkown
HY-RS10761	PMEPA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13866	STAG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21770	Stag1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28287	Stag1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	STAG1	VGNC	VGNC:46873
Felis catus	STAG1	VGNC	VGNC:82509
Rattus norvegicus	STAG1	RGD	RGD:1310744
Mus musculus	STAG1	MGD	MGI:1098658
Bos taurus	STAG1	VGNC	VGNC:35353
Macaca mulatta	STAG1	VGNC	VGNC:77901
Others	STAG1	NCBI