CEP85 - centrosomal protein 85 Gene

Also Known as CCDC21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64793

About CEP85

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,234,200-26,278,808 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 1 paralogue. Broad expression in testis (RPKM 23.4), heart (RPKM 8.7) and 20 other tissues.

Summary

This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

CEP85 Products (4)

mRNA Protein Name
NM_001281517.3 NP_001268446.1 centrosomal protein of 85 kDa isoform 2
NM_001281518.3 NP_001268447.1 centrosomal protein of 85 kDa isoform 3
NM_001319944.2 NP_001306873.1 centrosomal protein of 85 kDa isoform 4
NM_022778.5 NP_073615.2 centrosomal protein of 85 kDa isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
29712910 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18985028 GOA
Biological Process GO Annotation Evidence References Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
32107292 GOA
involved in centriole assembly IMP
IMP: Inferred from mutant phenotype
29712910 GOA
involved in centriole replication IMP
IMP: Inferred from mutant phenotype
29712910 GOA
involved in negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
26220856 GOA
involved in regulation of mitotic centrosome separation IMP
IMP: Inferred from mutant phenotype
26220856 GOA
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
32107292 GOA
located in centriole IDA
IDA: Inferred from direct assay
29712910 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
21399614 GOA
located in pericentriolar material IDA
IDA: Inferred from direct assay
26220856 GOA
located in spindle pole IDA
IDA: Inferred from direct assay
21399614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

centrosomal protein of 85 kDa

  • centrosomal protein 85kDa

CEP85 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CEP85 Q6P2H3 TERF1 Homo sapiens P54274
Pull Down
21044950
Cross
CEP85 Q6P2H3 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Pull Down
18985028
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Visual Agnosia

  • Primary Visual Agnosia
Primary Autosomal Recessive Microcephaly

  • Autosomal Recessive Primary Microcephaly

  • Mcph

  • True Microcephaly

  • Microcephalia Vera

  • Microcephaly Vera

  • Microcephaly Primary Hereditary

  • Microcephaly, Primary, Autosomal Recessive

  • Primary Microcephaly
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02526 CEP85 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02527 CEP85L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CEP85 VGNC VGNC:39140
Bos taurus CEP85 VGNC VGNC:27216
Mus musculus CEP85 MGD MGI:1917262
Macaca mulatta CEP85 VGNC VGNC:71096
Rattus norvegicus CEP85 RGD RGD:1311520
Felis catus CEP85 VGNC VGNC:60786
Others CEP85 NCBI