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Cat. No.: HY-125585

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Syk-IN-2

Syk-IN-2 (Page 78; 35) is a spleen tyrosine kinase (Syk) inhibitor.

For research use only. We do not sell to patients.

CAS No.: 1345458-66-3
Formula: C₂₁H₂₇FN₆
Molecular Weight:382.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Syk-IN-2 Chemical Structure

CAS No.: 1345458-66-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Syk-IN-2 (Page 78; 35) is a spleen tyrosine kinase (Syk) inhibitor^[1].

Chemical Information

CAS No. 1345458-66-3
Molecular Weight 382.49
Formula C₂₁H₂₇FN₆
SMILES

N(C[C@]1(F)CCCNC1)C=2C3=C(C=C(N2)C4=CN(C(C)(C)C)N=C4)N=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Molecular Biology

Polyacrylamide gel electrophoresis (PAGE) (<1 kb)
Gel electrophoresis is a method for separating biological macromolecules (such as nucleic acids or proteins) by forcing them through a gel matrix under an electric field.
Protocol for Protein Electrophoresis
Protein electrophoresis separates proteins in a polyacrylamide gel under an electric field; in SDS-PAGE, sodium dodecyl sulfate denatures proteins and gives them a broadly similar negative charge-to-mass ratio, so migration mainly reflects apparent molecular mass through the gel matrix. The readout is a stained protein band pattern: band position estimates apparent molecular mass using protein standards, band intensity reflects relative protein abundance within the linear range of staining/detection, and changes in band pattern can reflect protein expression, degradation, purification, or sample composition.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Francis Louis Atkinson, et al. 7-(1h-pyrazol-4-yl)-1,6-naphthyridine compounds as syk inhibitors. WO2011134971.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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