FCER1G - Fc epsilon receptor Ig Gene

Also Known as FCRG

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2207

About FCER1G

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,215,295-161,219,245 (from NCBI)

This gene has 3 transcripts (splice variants) and 106 orthologues. Broad expression in appendix (RPKM 140.4), spleen (RPKM 128.5) and 19 other tissues.

Summary

The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc Receptors. [provided by RefSeq, Jul 2008]

FCER1G Products (1)

mRNA	Protein	Name
NM_004106.2	NP_004097.1	high affinity immunoglobulin epsilon receptor subunit gamma precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	14967045	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8810294	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	28652325	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Fc-epsilon receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16735691	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Fc-gamma receptor III complex	IDA IDA: Inferred from direct assay	28652325	GOA
located in cell surface	IDA IDA: Inferred from direct assay	1535625	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16735691	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCER1G Protein Structure

TCR_zetazeta

ITAM

0
86 a.a.

Protein Preferred Names	Protein Names
high affinity immunoglobulin epsilon receptor subunit gamma	Fc fragment of IgE receptor Ig

FCER1G Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FCER1G	P30273	CD300C	Homo sapiens	Q08708	Anti Tag CoIP	20959446
Intra	FCER1G	P30273	CD300C	Homo sapiens	Q08708	Anti Tag CoIP	22291008

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bleeding Disorder, Platelet-Type, 11	BDPLT11 Glycoprotein Vi Deficiency Gp Vi Deficiency Platelet-Type Bleeding Disorder 11 Bleeding Diathesis Due To A Collagen Receptor Defect Bleeding Diathesis Due To Glycoprotein Vi Deficiency Platelet-Type Bleeding Disorder-11 Bleeding Disorder, Platelet Type 11 Hemorrhage
Malignant Iris Melanoma	Malignant Melanoma Of Iris Melanoma Of The Iris
Vernal Conjunctivitis	Conjunctivitis Vernal Conjunctivitis, Vernal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04823	FCER1G Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FCER1G	VGNC	VGNC:28931
Felis catus	FCER1G	VGNC	VGNC:107872
Mus musculus	FCER1G	MGD	MGI:95496
Rattus norvegicus	FCER1G	RGD	RGD:2599
Macaca mulatta	FCER1G	VGNC	VGNC:72629
Canis familiaris	FCER1G	VGNC	VGNC:40802
Others	FCER1G	NCBI