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Cat. No.: HY-112319

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(R,S)-MK-8457

(R,S)-MK-8457 is a stereoisomer of MK-8457. MK-8457 is a dual inhibitor of Syk and ZAP70.

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CAS No.: 1312518-84-5
Formule: C₂₄H₂₅F₃N₄O₃S
Masse moléculaire:506.54

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

(R,S)-MK-8457 Chemical Structure

CAS No.: 1312518-84-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- Essai clinique
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

(R,S)-MK-8457 is a stereoisomer of MK-8457. MK-8457 is a dual inhibitor of Syk and ZAP70^[1].

In Vitro

MK-8457 is primarily used in research on rheumatoid arthritis, and its application in hypertension has also been investigated^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1312518-84-5
Masse moléculaire 506.54
Formule C₂₄H₂₅F₃N₄O₃S
SMILES

O=C([C@@H]1C(C)(C)C[C@](C2=NC=C(C3=CC(NC4=NC=CC(C(F)(F)F)=N4)=CC(C)=C3)S2)(O)CC1)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Xie Z, et al. Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases. J Med Chem. 2021;64(3):1283-1345. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- Essai clinique
Chemical Information
Pureté et documentation
Références

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(R,S)-MK-8457

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Activité biologique

Chemical Information

Pureté et documentation

Références

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(R,S)-MK-8457 Related Classifications

HY-112319 Related Classifications