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Cat. No.: HY-112319A

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MK-8457

MK-8457 is a dual inhibitor of spleen tyrosine kinase (SYK) and zeta-chain-associated protein kinase 70 (ZAP70). MK-8457 can be used for the researches of rheumatoid arthritis, hypertension.

For research use only. We do not sell to patients.

CAS No.: 1312518-85-6
Formula: C₂₄H₂₅F₃N₄O₃S
Molecular Weight:506.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MK-8457 Chemical Structure

CAS No.: 1312518-85-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

MK-8457 is a dual inhibitor of spleen tyrosine kinase (SYK) and zeta-chain-associated protein kinase 70 (ZAP70). MK-8457 can be used for the researches of rheumatoid arthritis, hypertension^[1].

In Vitro

MK-8457 undergoes phase 2 clinical trial investigation for rheumatoid arthritis, terminated due to serious infections and completes phase 1 clinical trial evaluation for blood pressure reduction in hypertensive participants^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1312518-85-6
Molecular Weight 506.54
Formula C₂₄H₂₅F₃N₄O₃S
SMILES

O[C@]1(C2=NC=C(C3=CC(NC4=NC=CC(C(F)(F)F)=N4)=CC(C)=C3)S2)CC(C)([C@@H](CC1)C(O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xie Z, et al. Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases. J Med Chem. 2021;64(3):1283-1345. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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