ZAP70
ZAP70 (zeta-chain-associated protein kinase of 70 kDa) is the T-cell counterpart of SYK and the indispensable signal transducer of the T-cell antigen receptor. Its tandem SH2 domains bind doubly phosphorylated ITAMs of the CD3 and zeta chains after LCK phosphorylation, releasing ZAP70 autoinhibition and enabling phosphorylation of LAT and SLP-76, which assemble the LAT signalosome driving thymocyte development and T-cell activation. Human ZAP70 deficiency causes a form of severe combined immunodeficiency with absent CD8 T cells. In chronic lymphocytic leukemia, leukemic B cells aberrantly express ZAP70, exploiting it as a surrogate kinase for their dysfunctional B-cell receptor, and high ZAP70 marks aggressive disease and BCR-signaling competence.
-
ZAP70 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
