1. Protein Tyrosine Kinase/RTK
    Neuronal Signaling
    GPCR/G Protein
  2. Syk
    5-HT Receptor
  3. Syk Inhibitor II

Syk Inhibitor II 

Cat. No.: HY-112390A Purity: 98.05%
Handling Instructions

Syk Inhibitor II is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect.

For research use only. We do not sell to patients.

Syk Inhibitor II Chemical Structure

Syk Inhibitor II Chemical Structure

CAS No. : 726695-51-8

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5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 400 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Syk Inhibitor II is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect[1].

IC50 & Target[1]

Syk

41 nM (IC50)

serotonin

460 nM (IC50)

PKCε

5.1 μM (IC50)

PKCβ2

11 μM (IC50)

ZAP-70

11.2 μM (IC50)

Btk

15.5 μM (IC50)

Itk

22.6 μM (IC50)

In Vitro

Syk Inhibitor II (compound 9a) shows less potent against PKCε, PKCβ2, ZAP-70, Btk, and Itk with IC50 values of 5.1 µM, 11 µM, 11.2 µM, 15.5 µM, and 22.6 µM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Syk Inhibitor II (Compound 9a; 10-100 mg/kg) is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

340.30

Formula

C₁₄H₁₅F₃N₆O

CAS No.

726695-51-8

SMILES

O=C(C1=CN=C(NCCN)N=C1NC2=CC=CC(C(F)(F)F)=C2)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (14.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9386 mL 14.6929 mL 29.3858 mL
5 mM 0.5877 mL 2.9386 mL 5.8772 mL
10 mM 0.2939 mL 1.4693 mL 2.9386 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Syk Inhibitor IISyk5-HT ReceptorSpleen tyrosine kinaseSerotonin Receptor5-hydroxytryptamine ReceptorAnti-allergicATP-competitivepyrimidine-carboxamideantigenInhibitorinhibitorinhibit

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Syk Inhibitor II
Cat. No.:
HY-112390A
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