1. Protein Tyrosine Kinase/RTK
    PI3K/Akt/mTOR
  2. Syk
    PI3K
  3. SRX3207

SRX3207 

Cat. No.: HY-136198
Handling Instructions

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression.

For research use only. We do not sell to patients.

SRX3207 Chemical Structure

SRX3207 Chemical Structure

CAS No. : 2254693-15-5

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Description

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression[1][2].

IC50 & Target[2]

Syk

10.7 nM (IC50)

PI3Kα

861 nM (IC50)

PI3Kδ

1280 nM (IC50)

PI3Kγ

11100 nM (IC50)

Zap70

1300 nM (IC50)

In Vitro

SRX3207 (10 μmol/L) is able to block p-AKT at concentration[1].
SRX3207 has sufficient solubility in water (43 μmol/L)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SRX3207 (10 mg/kg, orally) increases antitumor immune response[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LLC or B16 or B16-OVA or CT26 (1 × 105) cells were injected subcutaneously into syngeneic mice[1].
Dosage: 10 mg/kg.
Administration: Orally, starting from day 10 when tumors reached 100 mm3 until tumors were harvested on day 21.
Result: Blocked phosphorylation of Syk at 348 site and Y525/526 site.
Blocked immunosuppressive MΦ polarization.
Blocked tumor growth and increased survival effectively.
Molecular Weight

555.65

Formula

C₂₉H₂₉N₇O₃S

CAS No.

2254693-15-5

SMILES

O=C1C2=C(C(C3=CC=C(NC4=NC=CC(N5N=C(C)C(CN6CCC6)=C5)=N4)C=C3)=CS2)OC(N7CCOCC7)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SRX3207SRX 3207SRX-3207SykPI3KSpleen tyrosine kinasePhosphoinositide 3-kinaseLLCB16B16-OVACT26TMECD8LewislungcarcinomamelanomaInhibitorinhibitorinhibit

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Product Name:
SRX3207
Cat. No.:
HY-136198
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