1. Protein Tyrosine Kinase/RTK
    PI3K/Akt/mTOR
  2. Syk
    PI3K
  3. SRX3207

SRX3207 

Cat. No.: HY-136198
Handling Instructions

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor. SRX3207 possesses anti-tumor activity.

For research use only. We do not sell to patients.

SRX3207 Chemical Structure

SRX3207 Chemical Structure

CAS No. : 2254693-15-5

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Description

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor. SRX3207 possesses anti-tumor activity[1].

In Vitro

SRX3207 (10 μmol/L) is able to block p-AKT at concentration[1].
SRX3207 has sufficient solubility in water (43 μmol/L)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SRX3207 (10 mg/kg, orally) increases antitumor immune response[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LLC or B16 or B16-OVA or CT26 (1 × 105) cells were injected subcutaneously into syngeneic mice[1].
Dosage: 10 mg/kg.
Administration: Orally, starting from day 10 when tumors reached 100 mm3 until tumors were harvested on day 21.
Result: Blocked phosphorylation of Syk at 348 site and Y525/526 site.
Blocked immunosuppressive MΦ polarization.
Blocked tumor growth and increased survival effectively.
Molecular Weight

555.65

Formula

C₂₉H₂₉N₇O₃S

CAS No.

2254693-15-5

SMILES

O=C1C2=C(C(C3=CC=C(NC4=NC=CC(N5N=C(C)C(CN6CCC6)=C5)=N4)C=C3)=CS2)OC(N7CCOCC7)=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SRX3207SRX 3207SRX-3207SykPI3KSpleen tyrosine kinasePhosphoinositide 3-kinaseLLCB16B16-OVACT26TMECD8LewislungcarcinomamelanomaInhibitorinhibitorinhibit

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