1. Protein Tyrosine Kinase/RTK
    PI3K/Akt/mTOR
  2. Syk
    PI3K
  3. SRX3207

SRX3207 

Cat. No.: HY-136198 Purity: 98.92%
Handling Instructions

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression.

For research use only. We do not sell to patients.

SRX3207 Chemical Structure

SRX3207 Chemical Structure

CAS No. : 2254693-15-5

Size Price Stock Quantity
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 680 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3400 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression[1][2].

IC50 & Target[2]

Syk

10.7 nM (IC50)

PI3Kα

861 nM (IC50)

PI3Kδ

1280 nM (IC50)

PI3Kγ

11100 nM (IC50)

Zap70

1300 nM (IC50)

In Vitro

SRX3207 (10 μmol/L) is able to block p-AKT at concentration[1].
SRX3207 has sufficient solubility in water (43 μmol/L)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SRX3207 (10 mg/kg, orally) increases antitumor immune response[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LLC or B16 or B16-OVA or CT26 (1 × 105) cells were injected subcutaneously into syngeneic mice[1].
Dosage: 10 mg/kg.
Administration: Orally, starting from day 10 when tumors reached 100 mm3 until tumors were harvested on day 21.
Result: Blocked phosphorylation of Syk at 348 site and Y525/526 site.
Blocked immunosuppressive MΦ polarization.
Blocked tumor growth and increased survival effectively.
Molecular Weight

555.65

Formula

C₂₉H₂₉N₇O₃S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (9.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7997 mL 8.9985 mL 17.9969 mL
5 mM 0.3599 mL 1.7997 mL 3.5994 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.92%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SRX3207
Cat. No.:
HY-136198
Quantity:
MCE Japan Authorized Agent: