2. Protein Tyrosine Kinase/RTK
    PI3K/Akt/mTOR
  3. Syk
    PI3K
  4. SRX3207

SRX3207 

Cat. No.: HY-136198 Purity: 98.92%
COA Handling Instructions

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression.

For research use only. We do not sell to patients.

SRX3207 Chemical Structure

SRX3207 Chemical Structure

CAS No. : 2254693-15-5

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5 mg USD 440 In-stock
10 mg USD 748 In-stock
25 mg USD 1485 In-stock
50 mg USD 2420 In-stock
100 mg USD 3740 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression[1][2].

IC50 & Target[2]

Syk

10.7 nM (IC50)

PI3Kα

861 nM (IC50)

PI3Kδ

1280 nM (IC50)

PI3Kγ

11100 nM (IC50)

Zap70

1300 nM (IC50)

In Vitro

SRX3207 (10 μmol/L) is able to block p-AKT at concentration[1].
SRX3207 has sufficient solubility in water (43 μmol/L)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

SRX3207 (10 mg/kg, orally) increases antitumor immune response[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LLC or B16 or B16-OVA or CT26 (1 × 105) cells were injected subcutaneously into syngeneic mice[1].
Dosage: 10 mg/kg.
Administration: Orally, starting from day 10 when tumors reached 100 mm3 until tumors were harvested on day 21.
Result: Blocked phosphorylation of Syk at 348 site and Y525/526 site.
Blocked immunosuppressive MΦ polarization.
Blocked tumor growth and increased survival effectively.
Molecular Weight

555.65

Appearance

Solid

Formula

C29H29N7O3S
CAS No.
SMILES

O=C1C2=C(C(C3=CC=C(NC4=NC=CC(N5N=C(C)C(CN6CCC6)=C5)=N4)C=C3)=CS2)OC(N7CCOCC7)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (9.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7997 mL 8.9985 mL 17.9969 mL
5 mM 0.3599 mL 1.7997 mL 3.5994 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 98.92%

COA (251 KB) HNMR (281 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

SRX32072254693-15-5SRX 3207SRX-3207SykPI3KSpleen tyrosine kinasePhosphoinositide 3-kinaseLLCB16B16-OVACT26TMECD8LewislungcarcinomamelanomaInhibitorinhibitorinhibit

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