Syk Inhibitor II hydrochloride
Based on 2 publication(s) in Google Scholar
Syk Inhibitor II hydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II hydrochloride inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II hydrochloride shows less potent against other kinases and has anti-allergic effect.
For research use only. We do not sell to patients.
- CAS No.: 2490508-82-0
- Formula: C14H16ClF3N6O
- Molecular Weight:376.76
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Syk Inhibitor II hydrochloride
MoreAll 5-HT Receptor Isoforms
More
Biological Activity
Description
IC50 & Target
[1]|
5-HT Receptor 460 nM (IC50) |
In Vitro
Syk Inhibitor II (compound 9a) hydrochloride shows less potent against PKCε, PKCβ2, ZAP-70, Btk, and Itk with IC50 values of 5.1 µM, 11 µM, 11.2 µM, 15.5 µM, and 22.6 µM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:ICR mice[1]
-
Dosage:10, 30, 100 mg/kg
-
Administration:S.c.; 30 min before antigen challenge
-
Result:Inhibited the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg.
Chemical Information
-
CAS No. 2490508-82-0
-
Molecular Weight 376.76
-
Formula C14H16ClF3N6O
-
SMILES
O=C(C1=CN=C(NCCN)N=C1NC2=CC=CC(C(F)(F)F)=C2)N.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Inflammation
Oroxylin A-induced Trained Immunity Promotes LC3-associated Phagocytosis in Macrophage in Protecting Mice Against Sepsis. [Abstract]2024 Dec;47(6):2196-2214. PMID: 38739341 -
Endocrinology
MiR-143 targets SYK to regulate NEFA uptake and contribute to thermogenesis in male mice. [Abstract]2023 Aug 1;164(9):bqad114. PMID: 37486737
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Syk Inhibitor II hydrochloride Related Classifications
HY-112390C Related Classifications
Powered by Bioz