1. Protein Tyrosine Kinase/RTK
  2. Syk
  3. Syk-IN-4

Syk-IN-4 

Cat. No.: HY-131341
Handling Instructions

Syk-IN-4 is a potent, selective and orally bioavailable SYK inhibitor with an IC50 of 0.31 nM. SYK has emerged as a potential target for autoimmunity and hematological cancers.

For research use only. We do not sell to patients.

Syk-IN-4 Chemical Structure

Syk-IN-4 Chemical Structure

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Description

Syk-IN-4 is a potent, selective and orally bioavailable SYK inhibitor with an IC50 of 0.31 nM. SYK has emerged as a potential target for autoimmunity and hematological cancers[1].

IC50 & Target

IC50: 0.31 nM (SYK)[1]

In Vitro

Syk-IN-4 is a potent inhibitor of hERG with an IC50 of 3.0 μM[1].
Syk-IN-4 inhibits SUDHL-4 and T cell proliferation with GI50s of 0.24 and 2.6 µM, respectively[1].

In Vivo

Syk-IN-4 exhibits moderate oral bioavailability (60%) following oral administration (1 mg/kg) in male Hans Wistar rats[1].
Syk-IN-4 exhibits high plasma clearance (151 mL/min/kg) combined with large volumes of distribution (1.0 L/kg respectively) following i.v. administration (0.5 mg/kg) in male Hans Wistar rats[1].

Molecular Weight

419.48

Formula

C₂₁H₂₅N₉O

SMILES

CC1=NN(C=C1CN(C)C)C2=NC(NC3=CC=C(N(C)N=C4C(NC)=O)C4=C3)=NC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Syk-IN-4SykSpleen tyrosine kinaseautoimmunityhematologicalInhibitorinhibitorinhibit

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