Syk Inhibitor II dihydrochloride dihydrate
Based on 2 publication(s) in Google Scholar
Syk Inhibitor II dihydrochloride dihydrate is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride dihydrate inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride dihydrate shows less potent against other kinases and has anti-allergic effect.
For research use only. We do not sell to patients.
- CAS No.: 1965323-05-0
- Formula: C14H21Cl2F3N6O3
- Molecular Weight:449.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Syk Inhibitor II dihydrochloride dihydrate
MoreAll 5-HT Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Syk 41 nM (IC50) |
serotonin 460 nM (IC50) |
PKCε 5.1 μM (IC50) |
PKCβ2 11 μM (IC50) |
ZAP-70 11.2 μM (IC50) |
Btk 15.5 μM (IC50) |
Itk 22.6 μM (IC50) |
In Vitro
Syk Inhibitor II (compound 9a) dihydrochloride dihydrate shows less potent against PKCε, PKCβ2, ZAP-70, Btk, and Itk with IC50 values of 5.1 µM, 11 µM, 11.2 µM, 15.5 µM, and 22.6 µM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1965323-05-0
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Molecular Weight 449.26
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Formula C14H21Cl2F3N6O3
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SMILES
O=C(C1=CN=C(NCCN)N=C1NC2=CC=CC(C(F)(F)F)=C2)N.[H]Cl.[H]Cl.O.O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Inflammation
Oroxylin A-induced Trained Immunity Promotes LC3-associated Phagocytosis in Macrophage in Protecting Mice Against Sepsis. [Abstract]2024 Dec;47(6):2196-2214. PMID: 38739341 -
Endocrinology
MiR-143 targets SYK to regulate NEFA uptake and contribute to thermogenesis in male mice. [Abstract]2023 Aug 1;164(9):bqad114. PMID: 37486737
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Syk Inhibitor II dihydrochloride dihydrate Related Classifications
HY-112390B Related Classifications
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