1. Protein Tyrosine Kinase/RTK
    GPCR/G Protein
    Neuronal Signaling
  2. Syk
    5-HT Receptor
  3. Syk Inhibitor II dihydrochloride dihydrate

Syk Inhibitor II dihydrochloride dihydrate 

Cat. No.: HY-112390B
Handling Instructions

Syk Inhibitor II dihydrochloride dihydrate is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride dihydrate inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride dihydrate shows less potent against other kinases and has anti-allergic effect.

For research use only. We do not sell to patients.

Syk Inhibitor II dihydrochloride dihydrate Chemical Structure

Syk Inhibitor II dihydrochloride dihydrate Chemical Structure

CAS No. : 1965323-05-0

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Description

Syk Inhibitor II dihydrochloride dihydrate is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride dihydrate inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride dihydrate shows less potent against other kinases and has anti-allergic effect[1].

IC50 & Target[1]

Syk

41 nM (IC50)

serotonin

460 nM (IC50)

PKCε

5.1 μM (IC50)

PKCβ2

11 μM (IC50)

ZAP-70

11.2 μM (IC50)

Btk

15.5 μM (IC50)

Itk

22.6 μM (IC50)

In Vitro

Syk Inhibitor II (compound 9a) dihydrochloride dihydrate shows less potent against PKCε, PKCβ2, ZAP-70, Btk, and Itk with IC50 values of 5.1 µM, 11 µM, 11.2 µM, 15.5 µM, and 22.6 µM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride dihydrate is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

449.26

Formula

C14H21Cl2F3N6O3

CAS No.
SMILES

O=C(C1=CN=C(NCCN)N=C1NC2=CC=CC(C(F)(F)F)=C2)N.[H]Cl.[H]Cl.O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
Syk Inhibitor II dihydrochloride dihydrate
Cat. No.:
HY-112390B
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