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Cat. No.: HY-112390

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Syk Inhibitor II dihydrochloride

Name: Syk Inhibitor II dihydrochloride
Brand: MedChemExpress
SKU: HY-112390
Availability: PreOrder

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Syk Inhibitor II dihydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC₅₀ of 41 nM. Syk Inhibitor II dihydrochloride inhibits 5-HT release from RBL-cells with an IC₅₀ of 460 nM. Syk Inhibitor II dihydrochloride shows less potent against other kinases and has anti-allergic effect.

For research use only. We do not sell to patients.

CAS No.: 227449-73-2
Formula: C₁₄H₁₇Cl₂F₃N₆O
Molecular Weight:413.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Syk Inhibitor II dihydrochloride Chemical Structure

CAS No.: 227449-73-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

5-HT Receptor

460 nM (IC₅₀)

All 5-HT Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RBL-2H3	IC₅₀	460 nM Compound: K00592a, Pyrimidineamide1	Inhibition of FcepsilonRI-mediated 5-HT release in rat RBL2H3 cells Inhibition of FcepsilonRI-mediated 5-HT release in rat RBL2H3 cells	[PMID: 18077363]

In Vitro

Syk Inhibitor II (compound 9a) dihydrochloride shows less potent against PKCε, PKCβ2, ZAP-70, Btk, and Itk with IC₅₀ values of 5.1 µM, 11 µM, 11.2 µM, 15.5 µM, and 22.6 µM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID₅₀ value of 13.2 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice^[1]
Dosage:

10, 30, 100 mg/kg
Administration:

S.c.; 30 min before antigen challenge
Result:

Inhibited the anaphylaxis reaction dose-dependently with an ID₅₀ value of 13.2 mg/kg.

Chemical Information

CAS No. 227449-73-2
Molecular Weight 413.23
Formula C₁₄H₁₇Cl₂F₃N₆O
SMILES

O=C(C1=CN=C(NCCN)N=C1NC2=CC=CC(C(F)(F)F)=C2)N.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Inflammation

Oroxylin A-induced Trained Immunity Promotes LC3-associated Phagocytosis in Macrophage in Protecting Mice Against Sepsis. [Abstract]

2024 Dec;47(6):2196-2214. PMID: 38739341
Endocrinology

MiR-143 targets SYK to regulate NEFA uptake and contribute to thermogenesis in male mice. [Abstract]

2023 Aug 1;164(9):bqad114. PMID: 37486737

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hiroyuki Hisamichi, et al. Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Syk Inhibitor II dihydrochloride

2 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References

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Syk Inhibitor II dihydrochloride

Publications Citing Use of MedChemExpress (MCE) Syk Inhibitor II dihydrochloride

All 5-HT Receptor Isoforms