1. Protein Tyrosine Kinase/RTK
  2. Syk
  3. OXSI-2


Cat. No.: HY-112386
Handling Instructions

OXSI-2 is a bioavailable, cell-permeable Syk inhibitor with an EC50 of 313 nM and an IC50 of 14 nM.

For research use only. We do not sell to patients.

OXSI-2 Chemical Structure

OXSI-2 Chemical Structure

CAS No. : 622387-85-3

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OXSI-2 is a bioavailable, cell-permeable Syk inhibitor with an EC50 of 313 nM and an IC50 of 14 nM[1][2].

In Vitro

OXSI-2 (2 μM) completely inhibits Convulxin-induced platelet aggregation and shape change. OXSI-2 (2 μM) also completely blocks GPVI-mediated dense granule release. OXSI-2 (100 nM) does not affect the platelet functional responses induced by Convulxin, and modest shape change is still evident at 1 μM[1].
Adaptor protein LAT is a known substrate of Syk Kinase. OXSI-2 completely inhibits LAT Y191 phosphorylation. OXSI-2 inhibits Syk mediated events in platelets[1].
OXSI-2 (2 μM) inhibits inflammasome assembly, caspase-1 activation, IL-1β processing and release, mitochondrial ROS generation, and pyroptotic cell death[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Aspirin-treated, washed human platelets
Concentration: 2 μM
Incubation Time:
Result: Completely inhibited Syk-mediated LAT Y191 phosphorylation.
Molecular Weight





Room temperature in continental US; may vary elsewhere.


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