2. Protein Tyrosine Kinase/RTK
  3. Syk
  4. OXSI-2

OXSI-2 is a bioavailable, cell-permeable Syk inhibitor with an EC50 of 313 nM and an IC50 of 14 nM.

For research use only. We do not sell to patients.

OXSI-2 Chemical Structure

OXSI-2 Chemical Structure

CAS No. : 622387-85-3

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500 μg USD 74 In-stock

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Based on 1 publication(s) in Google Scholar

OXSI-2 Related Antibodies

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Description

OXSI-2 is a bioavailable, cell-permeable Syk inhibitor with an EC50 of 313 nM and an IC50 of 14 nM[1][2].

In Vitro

OXSI-2 (2 μM) completely inhibits Convulxin-induced platelet aggregation and shape change. OXSI-2 (2 μM) also completely blocks GPVI-mediated dense granule release. OXSI-2 (100 nM) does not affect the platelet functional responses induced by Convulxin, and modest shape change is still evident at 1 μM[1].
Adaptor protein LAT is a known substrate of Syk Kinase. OXSI-2 completely inhibits LAT Y191 phosphorylation. OXSI-2 inhibits Syk mediated events in platelets[1].
OXSI-2 (2 μM) inhibits inflammasome assembly, caspase-1 activation, IL-1β processing and release, mitochondrial ROS generation, and pyroptotic cell death[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OXSI-2 Related Antibodies

Western Blot Analysis[1]

Cell Line: Aspirin-treated, washed human platelets
Concentration: 2 μM
Incubation Time:
Result: Completely inhibited Syk-mediated LAT Y191 phosphorylation.
Molecular Weight

353.40

Formula

C18H15N3O3S
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=S(C1=CC2=C(NC(/C2=C/C3=CN(C)C4=C3C=CC=C4)=O)C=C1)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (28.30 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8297 mL 14.1483 mL 28.2965 mL
5 mM 0.5659 mL 2.8297 mL 5.6593 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8297 mL 14.1483 mL 28.2965 mL 70.7414 mL
5 mM 0.5659 mL 2.8297 mL 5.6593 mL 14.1483 mL
10 mM 0.2830 mL 1.4148 mL 2.8297 mL 7.0741 mL
15 mM 0.1886 mL 0.9432 mL 1.8864 mL 4.7161 mL
20 mM 0.1415 mL 0.7074 mL 1.4148 mL 3.5371 mL
25 mM 0.1132 mL 0.5659 mL 1.1319 mL 2.8297 mL
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OXSI-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OXSI-2622387-85-3OXSI2OXSI 2SykSpleen tyrosine kinaseInflammasomePyroptosisInflammationPotassiumTyrosinekinaseSrcGPVIsignalingPARPiceatannolInhibitorinhibitorinhibit

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