622387-85-3
622387-85-3
Chemical Structure
OXSI-2
- CAS No.: 622387-85-3
- Formula:C18H15N3O3S
- Molecular Weight:353.40
IUPAC Name: (E)-3-((1-methyl-1H-indol-3-yl)methylene)-2-oxoindoline-5-sulfonamide
InChIKey: MLKHXLFEYOOYEY-OVCLIPMQSA-N
SMILES: O=S(C1=CC2=C(NC(/C2=C/C3=CN(C)C4=C3C=CC=C4)=O)C=C1)(N)=O
Biological Activity: OXSI-2 is a bioavailable, cell-permeable Syk inhibitor with an EC50 of 313 nM and an IC50 of 14 nM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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OXSI-2 | 99.9% | OXSI-2 is a bioavailable, cell-permeable Syk inhibitor with an EC50 of 313 nM and an IC50 of 14 nM. | ||||||||||||||||||||
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References
- [1]. Kamala Bhavaraju, et al. Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets. Eur J Pharmacol. 2008 Feb 12;580(3):285-90. [Content Brief]
- [2]. Jordan R Yaron, et al. The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux. Biochem Biophys Res Commun. 2016 Apr 8;472(3):545-50. [Content Brief]
Keywords
