1. Protein Tyrosine Kinase/RTK
  2. Syk
  3. Fostamatinib

Fostamatinib (Synonyms: R788)

Cat. No.: HY-13038A Purity: 99.20%
Handling Instructions

Fostamatinib (R788), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.

For research use only. We do not sell to patients.

Fostamatinib Chemical Structure

Fostamatinib Chemical Structure

CAS No. : 901119-35-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 123 In-stock
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 432 In-stock
Estimated Time of Arrival: December 31
100 mg USD 708 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Fostamatinib:

Top Publications Citing Use of Products
  • Biological Activity

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Description

Fostamatinib (R788), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.

IC50 & Target

Syk

Clinical Trial
Molecular Weight

580.46

Formula

C₂₃H₂₆FN₆O₉P

CAS No.

901119-35-5

SMILES

COC1=CC(NC2=NC=C(C(NC3=NC(N4COP(O)(O)=O)=C(C=C3)OC(C)(C)C4=O)=N2)F)=CC(OC)=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (107.67 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7228 mL 8.6139 mL 17.2277 mL
5 mM 0.3446 mL 1.7228 mL 3.4455 mL
10 mM 0.1723 mL 0.8614 mL 1.7228 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

FostamatinibR788R 788R-788SykSpleen tyrosine kinaseInhibitorinhibitorinhibit

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Product Name:
Fostamatinib
Cat. No.:
HY-13038A
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