1. Epigenetics
    TGF-beta/Smad
    Metabolic Enzyme/Protease
  2. PKC
    Phosphatase
    Endogenous Metabolite
  3. D-erythro-Sphingosine

D-erythro-Sphingosine (Synonyms: Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine)

Cat. No.: HY-101047 Purity: >98.0%
Handling Instructions

D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator.

For research use only. We do not sell to patients.

D-erythro-Sphingosine Chemical Structure

D-erythro-Sphingosine Chemical Structure

CAS No. : 123-78-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
25 mg USD 80 In-stock
Estimated Time of Arrival: December 31
50 mg USD 140 In-stock
Estimated Time of Arrival: December 31
100 mg USD 210 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

IC50 & Target[1][2][3][4]

p32

8 μM (EC50)

PKC

 

PP2A

 

Human Endogenous Metabolite

 

In Vitro

A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines[1]. D-erythro-Sphingosine inhibits protein kinase C in vitro[2]. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells[3].

Molecular Weight

299.49

Formula

C₁₈H₃₇NO₂

CAS No.

123-78-4

SMILES

CCCCCCCCCCCCC/C=C/[[email protected]@H](O)[[email protected]@H](N)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (139.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3390 mL 16.6950 mL 33.3901 mL
5 mM 0.6678 mL 3.3390 mL 6.6780 mL
10 mM 0.3339 mL 1.6695 mL 3.3390 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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D-erythro-Sphingosine
Cat. No.:
HY-101047
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