1. Epigenetics
    TGF-beta/Smad
    Metabolic Enzyme/Protease
  2. PKC
    Endogenous Metabolite

D-erythro-Sphingosine (Synonyms: Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine)

Cat. No.: HY-101047
Handling Instructions

D-erythro-Sphingosine is a very potent activator of p32-kinase with an EC50 of 8 μM. D-erythro-Sphingosine inhibits protein kinase C (PKC).

For research use only. We do not sell to patients.

D-erythro-Sphingosine Chemical Structure

D-erythro-Sphingosine Chemical Structure

CAS No. : 123-78-4

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

D-erythro-Sphingosine is a very potent activator of p32-kinase with an EC50 of 8 μM. D-erythro-Sphingosine inhibits protein kinase C (PKC).

IC50 & Target[1][2][3]

p32

8 μM (EC50)

PKC

 

Human Endogenous Metabolite

 

In Vitro

A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines[1]. D-erythro-Sphingosine inhibits protein kinase C in vitro[2]. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells[3].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3390 mL 16.6950 mL 33.3901 mL
5 mM 0.6678 mL 3.3390 mL 6.6780 mL
10 mM 0.3339 mL 1.6695 mL 3.3390 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

299.49

Formula

C₁₈H₃₇NO₂

CAS No.

123-78-4

SMILES

CCCCCCCCCCCCC/C=C/[[email protected]@H](O)[[email protected]@H](N)CO

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
D-erythro-Sphingosine
Cat. No.:
HY-101047
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D-erythro-Sphingosine

Cat. No.: HY-101047