1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
    Phospholipase
  3. D-Erythro-dihydrosphingosine

D-Erythro-dihydrosphingosine 

Cat. No.: HY-W019838
Handling Instructions

D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

For research use only. We do not sell to patients.

D-Erythro-dihydrosphingosine Chemical Structure

D-Erythro-dihydrosphingosine Chemical Structure

CAS No. : 764-22-7

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Description

D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

D-Erythro-dihydrosphingosine (D-erythro-DHS) significantly inhibits mastoparan-, but not Na3VO4-, stimulated arachidonic acid release in PC12 cells. D-Erythro-dihydrosphingosine at 100 AM slightly inhibits [3H]Arachidonic acid release, and 5 μM Ionomycin alone stimulates the release significantly. In the presence of 5 μM Ionomycin, 100 μM C2-ceramide stimulates the release, but D-Erythro-dihydrosphingosine (100 μM) inhibits the release. D-Erythro-dihydrosphingosine inhibits arachidonic acid release in cells and/or cPLA2α activity[1].

Molecular Weight

301.51

Formula

C₁₈H₃₉NO₂

CAS No.

764-22-7

SMILES

CCCCCCCCCCCCCCC[[email protected]@H](O)[[email protected]@H](N)CO

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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D-Erythro-dihydrosphingosine
Cat. No.:
HY-W019838
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