1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
    Phospholipase

D-Erythro-dihydrosphingosine 

Cat. No.: HY-W019838
Handling Instructions

D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

For research use only. We do not sell to patients.

D-Erythro-dihydrosphingosine Chemical Structure

D-Erythro-dihydrosphingosine Chemical Structure

CAS No. : 764-22-7

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

D-Erythro-dihydrosphingosine (D-erythro-DHS) significantly inhibits mastoparan-, but not Na3VO4-, stimulated arachidonic acid release in PC12 cells. D-Erythro-dihydrosphingosine at 100 AM slightly inhibits [3H]Arachidonic acid release, and 5 μM Ionomycin alone stimulates the release significantly. In the presence of 5 μM Ionomycin, 100 μM C2-ceramide stimulates the release, but D-Erythro-dihydrosphingosine (100 μM) inhibits the release. D-Erythro-dihydrosphingosine inhibits arachidonic acid release in cells and/or cPLA2α activity[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3166 mL 16.5832 mL 33.1664 mL
5 mM 0.6633 mL 3.3166 mL 6.6333 mL
10 mM 0.3317 mL 1.6583 mL 3.3166 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

301.51

Formula

C₁₈H₃₉NO₂

CAS No.

764-22-7

SMILES

CCCCCCCCCCCCCCC[[email protected]@H](O)[[email protected]@H](N)CO

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
D-Erythro-dihydrosphingosine
Cat. No.:
HY-W019838
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D-Erythro-dihydrosphingosine

Cat. No.: HY-W019838