1. Metabolic Enzyme/Protease
    GPCR/G Protein
  2. Endogenous Metabolite
    LPL Receptor
  3. Sphingosine-1-phosphate

Sphingosine-1-phosphate (Synonyms: S1P)

Cat. No.: HY-108496 Purity: >98.0%
Handling Instructions

Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids.

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Sphingosine-1-phosphate Chemical Structure

Sphingosine-1-phosphate Chemical Structure

CAS No. : 26993-30-6

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Description

Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

S1P (1 μM) induces a significant Ca2+ releases in HEK293 cells under serum starvation conditions (1% FCS)[1].
In a functional Ca2+ assay, Suramin (HY-B0879) alone does not exert any effect on intracellular Ca2+ release via gpr3, gpr6 or gpr12. In contrast, S1P (1 μM) induces Ca2+ release of gpr3, gpr6 and gpr12 in the presence of Suramin (HY-B0879) various concentrations in transfected HEK293 cells[2].
In a functional Ca2+ assay,S1P (3-3000 nM) in the presence Suramin (300 μM), exhibits nanomolar EC50 values for gpr3 (EC50=29 nM), gpr6 (EC50=15 nM) and gpr12 (EC50=24 nM), rat gpr3 (EC50=68 nM),respectively in HEK293 cells[2].
S1P increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively)[3].

Molecular Weight

379.47

Formula

C₁₈H₃₈NO₅P

CAS No.

26993-30-6

SMILES

N[[email protected]@H](CO[P](O)(O)=O)[[email protected]](O)/C=C/CCCCCCCCCCCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

Sphingosine-1-phosphateS1PEndogenous MetaboliteLPL ReceptorLysophospholipid Receptorneuroprotectivesphingolipidlipid mediatorphospholipidintracellularsecond messengermobilizationca2+Inhibitorinhibitorinhibit

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