2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Sphingomyelin

Sphingomyelin is a eukaryotic sphingolipid and one of the major constituents of cell membranes and particularly abundant in the myelin sheath that surrounds neuronal axons. Sphingomyelin plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann–Pick disease.

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CAS No. : 85187-10-6

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Based on 1 publication(s) in Google Scholar

Sphingomyelin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Sphingomyelin

Histological Imaging/Staining
In Vivo Efficacy Study

    Sphingomyelin purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2025 Feb 11:e0221724.  [Abstract]

    Sphingomyelin (SM) significantly reduced inflammatory cell infiltration in the airways of HDM-induced asthmatic mice.

    Sphingomyelin purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2025 Feb 11:e0221724.  [Abstract]

    (C) BALF total cell count and BALF eosinophilia percentage among groups. (D) BALF IL-4, IL-5, and IL-13 levels among groups. The results showed that compared with the HDM group, Sphingomyelin (SM) administration will alleviate airway inflammation in mice, manifested by lower total cell counts, EOS percentage, and T2 cytokines.

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    Description

    Sphingomyelin is a eukaryotic sphingolipid and one of the major constituents of cell membranes and particularly abundant in the myelin sheath that surrounds neuronal axons. Sphingomyelin plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann–Pick disease[1][2][3][4].

    IC50 & Target

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    In Vitro

    Sphingomyelin metabolism resulting in the production of various interconvertible bioactive sphingolipids or derivatives such as ceramide, diacylglyceride, and sphingosine-1-phosphate. These bioactive lipids act on their specific targets within the cell and regulate various signal transduction pathways, thereby affecting cellular functions[1].
    Sphingomyelin enriched lipid raft mediated cell signaling[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Sphingomyelin Related Antibodies
    Clinical Trial
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [Sphingomyelin]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    Ethanol : 25 mg/mL (Need ultrasonic)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in Saline)

      Solubility: 1.67 mg/mL; Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 1.67 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (16.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    • Protocol 2

      Add each solvent one by one:  10% EtOH    90% Corn Oil

      Solubility: ≥ 1.67 mg/mL; Clear solution

      This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (16.7 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
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    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: ≥99.0%

    SDS (251 KB)

    COA (242 KB)

    Handling Instructions (2659 KB)
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    Sphingomyelin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sphingomyelin85187-10-6Endogenous MetaboliteInhibitorinhibitorinhibit

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