1-Palmitoyl-2-oleoyl-sn-glycero-3-PC
Based on 3 publication(s) in Google Scholar
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers.
For research use only. We do not sell to patients.
- Purity : 99.96%
- CAS No.: 26853-31-6
- Formula: C42H82NO8P
- Molecular Weight:760.08
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-W583868
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE -
HY-130463
POPG sodium -
HY-113424A
1,2-Dioleoyl-sn-glycero-3-phosphocholine -
HY-N0322
Cholesterol (from animal) -
HY-130462R
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Standard) -
HY-113498
Sphingomyelin -
HY-141613
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium -
HY-W714524
1-Palmitoyl-2-oleoyl-sn-glycero-3-PS sodium -
HY-109506
DPPC -
HY-112764
mPEG2000-DMG -
HY-Y0320C
Dimethyl sulfoxide -
HY-N0729
Linoleic acid
Publications Citing Use of MedChemExpress (MCE) 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC
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Biological Activity
Description
In Vitro
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC) is a phospholipid containing 16:0 and 18:1 fatty acids at the sn-1 and sn-2 positions, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 26853-31-6
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Appearance Solid
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Molecular Weight 760.08
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Formula C42H82NO8P
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Color White to off-white
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SMILES
CCCCCCCC/C=C\CCCCCCCC(O[C@H](COC(CCCCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O
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Synonyms
POPC
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (3)
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Journal Impact Factor
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Most Recent
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Cell Biosci
2025 Jul 4;15(1):95. PMID: 40615893 -
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Solvent & Solubility
In Vitro:
Ethanol : 50 mg/mL (65.78 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (1.64 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: 1.25 mg/mL (1.64 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 1.25 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (1.64 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (285 KB)
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SDS (647 KB)
- English - EN (647 KB)
- Français - FR (647 KB)
- Deutsch - DE (647 KB)
- Norwegian - NO (647 KB)
- Español - ES (647 KB)
- Swedish - SV (647 KB)
- Italian - IT (647 KB)
- Korean - KR (647 KB)
- Portuguese - PT (647 KB)
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Handling Instructions (2659 KB)
References
[1]. Moreno MJ, et al. Translocation of phospholipids and dithionite permeability in liquid-ordered and liquid-disordered membranes. Biophys J. 2006 Aug 1;91(3):873-81. [Content Brief]
[2]. Ferreira TM, et al. Cholesterol and POPC segmental order parameters in lipid membranes: solid state 1H-13C NMR and MD simulation studies. Phys Chem Chem Phys. 2013 Feb 14;15(6):1976-89. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 1.3157 mL | 6.5783 mL | 13.1565 mL | 32.8913 mL |
| 5 mM | 0.2631 mL | 1.3157 mL | 2.6313 mL | 6.5783 mL | |
| 10 mM | 0.1316 mL | 0.6578 mL | 1.3157 mL | 3.2891 mL | |
| 15 mM | 0.0877 mL | 0.4386 mL | 0.8771 mL | 2.1928 mL | |
| 20 mM | 0.0658 mL | 0.3289 mL | 0.6578 mL | 1.6446 mL | |
| 25 mM | 0.0526 mL | 0.2631 mL | 0.5263 mL | 1.3157 mL | |
| 30 mM | 0.0439 mL | 0.2193 mL | 0.4386 mL | 1.0964 mL | |
| 40 mM | 0.0329 mL | 0.1645 mL | 0.3289 mL | 0.8223 mL | |
| 50 mM | 0.0263 mL | 0.1316 mL | 0.2631 mL | 0.6578 mL | |
| 60 mM | 0.0219 mL | 0.1096 mL | 0.2193 mL | 0.5482 mL |
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC Related Classifications
HY-130462 Related Classifications
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