POPG sodium salt (Synonyms: PG(16:0/18:1); 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol))

Name: POPG sodium salt
Brand: MedChemExpress
SKU: HY-130463
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-130463 Reinheit: 99.23%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

POPG sodium salt is a negatively charged phospholipid. POPG sodium salt affects the interactions of membrane proteins with other molecules by changing the charge characteristics of the lipid environment. POPG sodium salt increases the apparent affinity of Gαq and Gβ₁γ₁ for activated NTS1. POPG sodium salt can interact with the positive charge of peptides. POPG sodium salt can be used in Parkinson's disease research.

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POPG sodium salt Chemische Struktur

CAS. Nr. : 268550-95-4

Größe	Verfügbarkeit	Menge
Solution
10 mM * 1 mL in Ethanol	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
200 mg	Angebot einholen
500 mg	Angebot einholen

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Other Forms of POPG sodium salt:

16:0-18:1 PG-d₃₁ Angebot einholen
POPG-d₆₂ Angebot einholen
1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol Angebot einholen

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Neurotensin Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

NTR1 NTR2

Biologische Aktivität
Reinheit & Dokumentation
Verweise
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Beschreibung

In Vitro

POPG sodium salt can be used in the preparation of nanoparticles capable of co-encapsulating and releasing hydrophilic peptide compounds^[1].
POPG sodium salt increases the apparent affinity of Gαq and Gβ₁γ₁ for activated NTS1^[2].
POPG sodium salt-formed bilayers can be penetrated by the antimicrobial peptide LL-37^[3].
The presence of POPG sodium salt lipids in the membrane enhances the binding of the PAP248-286 peptide^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

770.99

Formel

C₄₀H₇₆NaO₁₀P

CAS. Nr.

268550-95-4

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCC/C=C\CCCCCCCC(O[C@@H](COP(OCC(O)CO)(O[Na])=O)COC(CCCCCCCCCCCCCCC)=O)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 18.18 mg/mL (23.58 mM; ultrasonic and adjust pH to 4 with 1 M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 8.33 mg/mL (10.80 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2970 mL	6.4852 mL	12.9703 mL
5 mM	0.2594 mL	1.2970 mL	2.5941 mL
10 mM	0.1297 mL	0.6485 mL	1.2970 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (1.62 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 1.25 mg/mL (1.62 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 1.25 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.83 mg/mL (1.08 mM); Clear solution

This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (8.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 4

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 0.83 mg/mL (1.08 mM); Clear solution

This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (8.3 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Reinheit & Dokumentation

Purity: 99.23%

Select Batch:

Data Sheet (268 KB) SDS (647 KB)

COA (240 KB) HNMR (293 KB) RP-HPLC (249 KB) MS (85 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Kim MR, et al. Co-Encapsulation and Co-Delivery of Peptide Drugs via Polymeric Nanoparticles. Polymers (Basel). 2019;11(2):288. Published 2019 Feb 8. [Content Brief]

[2]. Inagaki S, et al. Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid. J Mol Biol. 2012 Mar 16;417(1-2):95-111. [Content Brief]

[3]. Zhao L, et al. Molecular Dynamics Simulations of Human Antimicrobial Peptide LL-37 in Model POPC and POPG Lipid Bilayers. Int J Mol Sci. 2018 Apr 13;19(4):1186. [Content Brief]

[4]. Agrawal N, et al. Investigating the Effects of the POPC-POPG Lipid Bilayer Composition on PAP248-286 Binding Using CG Molecular Dynamics Simulations. J Phys Chem B. 2023 Oct 26;127(42):9095-9101. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO	1 mM	1.2970 mL	6.4852 mL	12.9703 mL	32.4258 mL
	5 mM	0.2594 mL	1.2970 mL	2.5941 mL	6.4852 mL
	10 mM	0.1297 mL	0.6485 mL	1.2970 mL	3.2426 mL
DMSO	15 mM	0.0865 mL	0.4323 mL	0.8647 mL	2.1617 mL
DMSO	20 mM	0.0649 mL	0.3243 mL	0.6485 mL	1.6213 mL

POPG sodium salt Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

POPG268550-95-4PG(16:0/18:1)1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)LiposomeBiochemical Assay ReagentsNeurotensin Receptorpeptide Parkinson's diseaseInhibitorinhibitorinhibit

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POPG sodium salt (Synonyms: PG(16:0/18:1); 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol))

Kundenbewertung

Other Forms of POPG sodium salt:

POPG sodium salt Related Antibodies

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Neurotensin Receptor Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

POPG sodium salt Related Antibodies

Molaritätsrechner

Verdünnungsrechner

Complete Stock Solution Preparation Table

POPG sodium salt Related Classifications

Keywords:

Ihre kürzlich angesehenen Produkte:

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SAFETY DATA SHEET (SDS)

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