1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol  (Synonyms: POPG)

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (POPG) is an anionic phosphatidylglycerol that often serves as a key component to co-construct model phospholipid bilayers with phosphatidylcholine (e.g., at a 3:1 POPC:POPG ratio) for investigating the structure and dynamics of transmembrane proteins. 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol acts as a fundamental material for mimicking the physicochemical properties of biological membranes and enables the elucidation of membrane protein interaction mechanisms^[1][2].

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol renders the central transmembrane domain of the KCNE3 protein more rigid and stable than the electrolyte-exposed protein ends in a mixed phospholipid bilayer^[1].
1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (POPG) forms dynamic, transient clusters of 2-3 lipids via direct hydrogen bonds, sodium ion bridges, or one-water bridges in 4:1 and 5:1 POPC:POPG bilayers, with all interactions (including water-mediated phosphate bridges) exhibiting picosecond-scale dynamics and consistent hydrogen bonding profiles across both bilayer ratios^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

749.01

C₄₀H₇₇O₁₀P

185435-28-3

OCC(O)COP(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Marti J, Calero C. Modeling and simulation of lipid membranes[J]. Membranes, 2022, 12(6): 549.

  [2]. Karathanou K, et al. Dynamic Water Hydrogen-Bond Networks at the Interface of a Lipid Membrane Containing Palmitoyl-Oleoyl Phosphatidylglycerol. J Membr Biol. 2018;251(3):461-473.  [Content Brief]