1-Palmitoyl-2-oleoyl-sn-glycero-3-PE
Based on 1 publication(s) in Google Scholar
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines.
For research use only. We do not sell to patients.
- Purity : 99.49%
- CAS No.: 26662-94-2
- Formula: C39H76NO8P
- Molecular Weight:718.00
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-130462
1-Palmitoyl-2-oleoyl-sn-glycero-3-PCSaturated Monobasic Alcohol -
HY-130463
POPG sodiumPhospholipid -
HY-112005
DOPEFerroptosis Inhibitor -
HY-120991
1-Palmitoyl-2-linoleoyl-sn-glycero-3-PELipid -
HY-W040193
DSPCLiposome Compound -
HY-N0322
Cholesterol (from animal)ERRα Agonist -
HY-112530
1,2-Distearoyl-sn-glycero-3-phosphorylethanolaminePhosphoethanolamine (PE) Lipid -
HY-W322225
1,2-Dilauroyl-sn-glycero-3-phosphoethanolamineAnionic Phospholipid -
HY-107737
1,2-DLPCLRH-1 Agonist Ligand -
HY-W040268
1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamineBiochemical Assay Reagent -
HY-160202
18:1 Cardiolipin disodiumMgtA Modulator -
HY-W714524
1-Palmitoyl-2-oleoyl-sn-glycero-3-PS sodiumPhospholipid
Publications Citing Use of MedChemExpress (MCE) 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE
More
Biological Activity
Description
In Vitro
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (as a phospholipid component, molar ratio 30%) can significantly increase the expression level of luciferase mRNA in HEK293T and HeLa cells in the in vitro transfection experiment of lipid nanoparticles (LNPs)[2].
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (as a phospholipid component, molar ratio 30%) shows in vivo organ targeting experiments that the LNPs constructed with it mainly enriched in the liver, and the expression of luciferase activity in the liver is significantly higher than that in other organs such as the spleen[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 26662-94-2
-
Appearance Solid
-
Molecular Weight 718.00
-
Formula C39H76NO8P
-
Color White to off-white
-
SMILES
CCCCCCCC/C=C\CCCCCCCC(O[C@@H](COP(O)(OCCN)=O)COC(CCCCCCCCCCCCCCC)=O)=O
-
Synonyms
1,2-POPE; 16:0-18:1 PE
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
ACS Nano
Optimization of Lipid Nanoparticles for Safe and Versatile Lung-Targeted RNA Delivery and Disease Therapy. [Abstract]2026 Jun 2;20(21):15347-15362. PMID: 42138142
Solvent & Solubility
In Vitro:
Methanol : 2.5 mg/mL (3.48 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
-
RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
Purity & Documentation
-
Data Sheet (270 KB)
-
SDS (647 KB)
- English - EN (647 KB)
- Français - FR (647 KB)
- Deutsch - DE (647 KB)
- Norwegian - NO (647 KB)
- Español - ES (647 KB)
- Swedish - SV (647 KB)
- Italian - IT (647 KB)
- Korean - KR (647 KB)
- Portuguese - PT (647 KB)
-
Handling Instructions (2659 KB)
References
[1]. Álvarez-Benedicto E, et al. Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA). Biomater Sci. 2022 Jan 18;10(2):549-559. [Content Brief]
[2]. Guo L, et al. A liquid chromatography-tandem mass spectrometry method for measurement of N-modified phosphatidylethanolamines. Anal Biochem. 2010 Oct 15;405(2):236-45. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Methanol | 1 mM | 1.3928 mL | 6.9638 mL | 13.9276 mL | 34.8189 mL |
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE Related Classifications
HY-W583868 Related Classifications
Powered by Bioz