1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (Synonyms: 1,2-POPE; 16:0-18:1 PE)

Art. -Nr.: HY-W583868 Reinheit: 99.20%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines.

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1-Palmitoyl-2-oleoyl-sn-glycero-3-PE Chemische Struktur

CAS. Nr. : 26662-94-2

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Other Forms of 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE:

16:0-18:1 PE-d₃₁ In-stock
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d₆₂ Angebot einholen

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
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Beschreibung

In Vitro

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (as a phospholipid component, molar ratio 30%) can significantly increase the expression level of luciferase mRNA in HEK293T and HeLa cells in the in vitro transfection experiment of lipid nanoparticles (LNPs)^[2].
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (as a phospholipid component, molar ratio 30%) shows in vivo organ targeting experiments that the LNPs constructed with it mainly enriched in the liver, and the expression of luciferase activity in the liver is significantly higher than that in other organs such as the spleen^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

718.00

Formel

C₃₉H₇₆NO₈P

CAS. Nr.

26662-94-2

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCC/C=C\CCCCCCCC(O[C@@H](COP(O)(OCCN)=O)COC(CCCCCCCCCCCCCCC)=O)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

Methanol : 2.5 mg/mL (3.48 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3928 mL	6.9638 mL	13.9276 mL
5 mM	---	---	---
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.46%

Select Batch:

Data Sheet (266 KB) SDS (587 KB)

COA (239 KB) HNMR (318 KB) RP-HPLC (213 KB) MS (69 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Álvarez-Benedicto E, et al. Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA). Biomater Sci. 2022 Jan 18;10(2):549-559. [Content Brief]

[2]. Guo L, et al. A liquid chromatography-tandem mass spectrometry method for measurement of N-modified phosphatidylethanolamines. Anal Biochem. 2010 Oct 15;405(2):236-45. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Methanol

1 mM

1.3928 mL

6.9638 mL

13.9276 mL

34.8189 mL

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Palmitoyl-2-oleoyl-sn-glycero-3-PE26662-94-21,2-POPE 16:0-18:1 PELiposomephospholipiddrug deliveryInhibitorinhibitorinhibit

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