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    Metabolic Enzyme/Protease
  2. Estrogen Receptor/ERR
    Endogenous Metabolite
  3. Cholesterol

Cholesterol 

Cat. No.: HY-N0322 Purity: >98.0%
Handling Instructions

Cholesterol is the major sterol in mammals and is makes up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.

For research use only. We do not sell to patients.

Cholesterol Chemical Structure

Cholesterol Chemical Structure

CAS No. : 57-88-5

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Based on 4 publication(s) in Google Scholar

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Description

Cholesterol is the major sterol in mammals and is makes up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins[1][2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist[3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

GT1-7 hypothalamic cells subjected to Cholesterol depletion in vitro produced 20-31% reductions in cellular Cholesterol content. All Cholesterol-depleted neuron-derived cells, exhibit decreased phosphorylation/activation of IRS-1 and AKT following stimulation by insulin, insulin-like growth factor-1, or the neurotrophins (NGF and BDNF). Reduction in cellular Cholesterol also results in increased basal autophagy and impairment of induction of autophagy by glucose deprivation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Insulin-deficient diabetes in mice can lead to a reduction in brain Cholesterol synthesis, which occurs through a change in expression of Cholesterol synthesis enzymes and their upstream regulators SREBP2 and SCAP1[1].
The pool of Cholesterol in the whole animal is 2,200 mg/kg body weight. This is true for essentially all species from the mouse to the primate and indicates that the average concentration of Cholesterol in the whole animal is 2.2 mg/g fresh tissue[2].
The basal metabolic rate in the mouse is 170 kilocalories (kcal)/day/kg, and the flow of Cholesterol from all peripheral organs to the liver is greater than 100 mg/day/kg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

386.65

Formula

C₂₇H₄₆O

CAS No.

57-88-5

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 25 mg/mL (64.66 mM; Need ultrasonic)

DMSO : 0.79 mg/mL (2.04 mM; Need warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5863 mL 12.9316 mL 25.8632 mL
5 mM 0.5173 mL 2.5863 mL 5.1726 mL
10 mM 0.2586 mL 1.2932 mL 2.5863 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

CholesterolEstrogen Receptor/ERREndogenous MetaboliteDiabetesSREBP2insulinphosphorylationIRS-1AKTexocyticunesterifiedtransporterssignalingERRαInhibitorinhibitorinhibit

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Product Name:
Cholesterol
Cat. No.:
HY-N0322
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