SREBP2

By Targets:	Autophagy (1) Bacterial (1) Endogenous Metabolite (1) Estrogen Receptor/ERR (1) Fatty Acid Synthase (FASN) (2) Liposome (1) Ser/Thr Protease (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Metabolic Disease (1) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14452

Fatostatin 15+ Cited Publications 125B11	Fatty Acid Synthase (FASN)	Cancer
Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice ^[2].

HY-14452A

Fatostatin hydrobromide 15+ Cited Publications 125B11 hydrobromide	Fatty Acid Synthase (FASN)	Cancer
Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice ^[2].

HY-N0322

Cholesterol Maximum Cited Publications 20 Publications Verification	Liposome Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Metabolic Disease Cancer
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins ^[2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-W510159

5-O-Methylembelin	Ser/Thr Protease	Cardiovascular Disease
5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression .

HY-N10702

PCSK9-IN-9	Ser/Thr Protease	Cardiovascular Disease
PCSK9-IN-9 is an isocoumarins of natural origin. PCSK9-IN-9 can inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and *SREBP2* mRNA expression. PCSK9-IN-9 inhibits PCSK9 with an IC₅₀ value of 11.9 μM .

HY-B0444A

Maprotiline	Autophagy	Neurological Disease Cancer
Maprotiline is a highly selective noradrenergic reuptake blocker, has strong antidepressant efficacy. Maprotiline induces cancer cells apoptosis by targeting ERK signaling pathway and CRABP1. Maprotiline restrains cell proliferation and metastasis, exhibits anticancer effect ^[2].

Cat. No.	Product Name	Type

HY-N0322

Cholesterol 15+ Cited Publications	Drug Delivery
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins ^[2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

Cholesterol

15+ Cited Publications

Drug Delivery

Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins ^[2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0322

Cholesterol 15+ Cited Publications	Structural Classification Microorganisms Classification of Application Fields Anti-aging Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Cancer	Liposome Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins ^[2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-W510159

5-O-Methylembelin	Structural Classification Lysimachia vulgarisL. Source classification Coumarins Phenylpropanoids Plants Primulaceae	Ser/Thr Protease
5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression .

HY-N10702

PCSK9-IN-9	Structural Classification Lysimachia vulgarisL. Source classification Coumarins Phenylpropanoids Plants Primulaceae	Ser/Thr Protease
PCSK9-IN-9 is an isocoumarins of natural origin. PCSK9-IN-9 can inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and *SREBP2* mRNA expression. PCSK9-IN-9 inhibits PCSK9 with an IC₅₀ value of 11.9 μM .

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SREBP2

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