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Fatostatin A (Synonyms: 125B11)

Cat. No.: HY-14452 Purity: 99.81%
Handling Instructions

Fatostatin A is a inhibitor of SREBP that directly binds SCAP and blocks its ER-to-Golgi transport with IC50 of 2.5 and 10 μM in mammalian cells.

For research use only. We do not sell to patients.
Fatostatin A Chemical Structure

Fatostatin A Chemical Structure

CAS No. : 125256-00-0

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
5 mg USD 72 In-stock
10 mg USD 108 In-stock
25 mg USD 228 In-stock
50 mg USD 420 In-stock
100 mg USD 720 In-stock
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  • Biological Activity

  • Protocol

  • Technical Information

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  • References

Description

Fatostatin A is a inhibitor of SREBP that directly binds SCAP and blocks its ER-to-Golgi transport with IC50 of 2.5 and 10 μM in mammalian cells target: SREBP IC50: 2.5 ~10 μM In vitro: Fatostatin A suppress cell proliferation and anchorage-independent colony formation in both androgen-responsive LNCaP and androgen-insensitive C4-2B prostate cancer cells. [1] Fatostatin potently inhibited cell growth.[2] In vivo: Fatostatin A cause G2/M cell cycle arrest and induce apoptosis by increasing caspase-3/7 activity and the cleavages of caspase-3 and PARP. [1] μCT analyses show that fatostatin A treatment preserve bone mass and structure in the proximal tibial trabecular bone in the mouse RANKL-induced bone loss model.[3]

References
Molecular Weight

294.41

Formula

C₁₈H₁₈N₂S

CAS No.

125256-00-0

SMILES

CCCC1=NC=CC(C2=NC(C3=CC=C(C)C=C3)=CS2)=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 27 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Fatostatin A
Cat. No.:
HY-14452
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