Cholesterol (Water Soluble)
Based on 92 publication(s) in Google Scholar
Cholesterol Water Soluble is a major sterol in mammals, constituting 20-25% of the structural composition of the plasma membrane. The plasma membrane is highly permeable to water but relatively impermeable to ions and protons. Cholesterol Water Soluble plays an important role in determining the fluidity and permeability characteristics of membranes and the function of transporters and signaling proteins. Cholesterol Water Soluble is also an endogenous estrogen-related receptor alpha (ERRα) agonist. Cholesterol Water Soluble can be used to study the effects of cholesterol on potassium currents in inner hair cells.
(Note: This product is a mixture of Cholesterol and Methyl-β-cyclodextrin. The product specifications below only indicate the effective content of Cholesterol.)
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.0%
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보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Cholesterol (Water Soluble)
More- Signal Transduct Target Ther. 2025 Mar 24;10(1):101. [Abstract]
- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Mol Cancer. 2025 Jul 19;24(1):199. [Abstract]
- Mol Cancer. 2025 May 26;24(1):151. [Abstract]
- Nat Nanotechnol. 2021 Oct;16(10):1150-1160. [Abstract]
- Cell Metab. 2024 Nov 5;36(11):2402-2418.e10. [Abstract]
- Immunity. 2026 May 13:S1074-7613(26)00171-8. [Abstract]
- Immunity. 2024 May 14;57(5):1087-1104.e7. [Abstract]
- Cancer Commun (Lond). 2025 Aug;45(8):1010-1037. [Abstract]
- Nat Biomed Eng. 2025 Feb;9(2):215-233. [Abstract]
- Nat Aging. 2025 Aug 26. [Abstract]
- Cell Host Microbe. 2025 Dec 30:S1931-3128(25)00521-9. [Abstract]
- Nat Commun. 2024 Jan 2;15(1):162. [Abstract]
- Exp Mol Med. 2025 May;57(5):1089-1105. [Abstract]
- Redox Biol. 2025 Jul:84:103693. [Abstract]
- Redox Biol. 2023 Jun:62:102678. [Abstract]
- Nat Chem Biol. 2022 Nov;18(11):1196-1203. [Abstract]
- J Nanobiotechnology. 2022 Oct 20;20(1):454. [Abstract]
- Theranostics. 2021 Jan 1;11(2):841-860. [Abstract]
- Adv Sci (Weinh). 2026 Jun 19:e76165. [Abstract]
- Adv Sci (Weinh). 2026 Apr;13(24):e15606. [Abstract]
- Adv Sci (Weinh). 2025 Sep;12(34):e04195. [Abstract]
- Adv Sci (Weinh). 2024 Oct;11(38):e2402329. [Abstract]
- Adv Sci (Weinh). 2024 Sep;11(33):e2403640. [Abstract]
- Adv Sci (Weinh). 2023 Sep;10(27):e2206878. [Abstract]
- Cell Rep Med. 2026 Feb 17;7(2):102580. [Abstract]
- Cell Rep Med. 2026 Feb 17;7(2):102591. [Abstract]
- J Control Release. 2026 May 23:396:115047. [Abstract]
- J Control Release. 2026 Mar 14:114825. [Abstract]
- J Control Release. 2025 Aug 10:384:113907. [Abstract]
- Phytomedicine. 2025 Jul 25:143:156904. [Abstract]
- Phytomedicine. 2024 Mar:125:155299. [Abstract]
- Adv Healthc Mater. 2026 Jun;15(22):e05818. [Abstract]
- Mater Today Bio. 2026 Mar 2:37:102990. [Abstract]
- Adv Healthc Mater. 2026 Feb 21:e05684. [Abstract]
- Cell Death Discov. 2025 Feb 8;11(1):55. [Abstract]
- Cell Death Discov. 2024 May 29;10(1):263. [Abstract]
- Nat Struct Mol Biol. 2025 May;32(5):896-904. [Abstract]
- Sci China Life Sci. 2022 Feb;65(2):341-361. [Abstract]
- Proc Natl Acad Sci U S A. 2026 Jul 7;123(27):e2523789123.
- Int J Nanomedicine. 2026 Mar 20:21:577606. [Abstract]
- Int J Nanomedicine. 2025 Oct 22:20:12783-12804. [Abstract]
- Small Methods. 2025 Jun;9(6):e2401712. [Abstract]
- Free Radic Biol Med. 2024 Nov 1:224:232-245. [Abstract]
- EMBO Mol Med. 2024 Aug;16(8):1755-1790. [Abstract]
- ACS Appl Mater Interfaces. 2025 Oct 8;17(40):55861-55875. [Abstract]
- ACS Appl Mater Interfaces. 2024 Sep 4;16(35):46044-46052. [Abstract]
- NPJ Vaccines. 2025 Aug 14;10(1):193. [Abstract]
- J Ethnopharmacol. 2025 May 28:348:119877. [Abstract]
- Biochem Pharmacol. 2025 Aug 8;242(Pt 3):117223. [Abstract]
- Cell Biosci. 2025 Jul 4;15(1):95. [Abstract]
- Cell Mol Life Sci. 2024 Jul 6;81(1):289. [Abstract]
- Life Sci. 2025 Jun 1:370:123571. [Abstract]
- Polym Test. 2023 Dec 1, 108292.
- Life Sci. 2023 Aug 15:327:121698. [Abstract]
- Plant J. 2025 Nov;124(3):e70559. [Abstract]
- Anal Chim Acta. 2026 Jun 16;1418:345855.
- Int J Pharm. 2024 Oct 25:664:124608. [Abstract]
- Biomacromolecules. 2025 Jun 9;26(6):3563-3575. [Abstract]
- Commun Biol. 2026 Feb 7;9(1):373. [Abstract]
- Commun Biol. 2024 Nov 9;7(1):1476. [Abstract]
- Respir Res. 2024 Nov 7;25(1):399. [Abstract]
- Bioorg Chem. 2026 Apr:171:109526. [Abstract]
- One Health Adv. 2026 Jun 11;4(1):17.
- Sci Rep. 2025 May 26;15(1):18364. [Abstract]
- Cell Signal. 2024 Dec:124:111419. [Abstract]
- iScience. 2024 Apr 6;27(5):109676. [Abstract]
- Insect Biochem Mol Biol. 2026 Mar:188:104499. [Abstract]
- J Pharmacol Exp Ther. 2025 Dec 24.
- Nanomedicine. 2024 Jun:58:102745. [Abstract]
- Antiviral Res. 2023 Jan:209:105497. [Abstract]
- J Pharm Sci. 2024 Aug;113(8):2584-2594. [Abstract]
- Viruses. 2022 Mar 3;14(3):514. [Abstract]
- Pathol Res Pract. 2025 Sep:273:156138. [Abstract]
- Life Sci Alliance. 2022 Jan 4;5(3):e202101256. [Abstract]
- Vet Microbiol. 2026 Jun 17:320:111115. [Abstract]
- Vet Microbiol. 2024 Jan:288:109948. [Abstract]
- Part Part Syst Charact. 2024 Jun 12.
- Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868. [Abstract]
- Part Sci Technol. 2025 Jul 03.
- Lett Drug Des Discov. 2026 Feb 11.
- Traditional Medicine Research. 2025;10(4):20.
- Gene Rep. 2026 Jan 12;42:102429.
- Heliyon. 2026 Jan 22;12(2):e44534.
- SSRN. 2025 Oct 29.
- Res Sq. 2025 Jul 29.
- Cell Biomater. 2025 Aug 19.
- SSRN. 2025 Aug 29.
- Patent. US20250248939A1.
- SSRN. 2024 Feb 5.
- Patent. US20200376146A1.
- Patent. US20200376102A1.
Customer Validation & Images
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Cell Imaging/Staining
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Bio/Physico-chemical Assay
Biological Activity
(Note: This product is a mixture of Cholesterol and Methyl-β-cyclodextrin. The product specifications below only indicate the effective content of Cholesterol.)
In solution of 1mM water-soluble cholesterol, the amplitude of K currents in isolated IHCs is reversely changed[2].
Note:
Product is approximately 40 mg of Cholesterol per gram containing a balance of Methyl-B-cyclodextrin.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Color White to off-white
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SMILES
[Cholesterol (Water Soluble)]
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (92)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Intranasal prime-boost RNA vaccination elicits potent T cell response for lung cancer therapy. [Abstract]2025 Mar 24;10(1):101. PMID: 40122855 -
Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Mol Cancer
CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA. [Abstract]2025 Jul 19;24(1):199. PMID: 40684174 -
Mol Cancer
GP73-dependent regulation of exosome biogenesis promotes colorectal cancer liver metastasis. [Abstract]2025 May 26;24(1):151. PMID: 40414849
Cholesterol (Water Soluble) purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 May 26;24(1):151. [Abstract]
Analysis of interactions between GP73 and Cholesterol (0.1-10000 nM, 3 h), 25-HC, 27-HC, campesterol, and epicholesterol by MST.
Cholesterol (Water Soluble) purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 May 26;24(1):151. [Abstract]
Analysis of interactions between Cholesterol (0.1-1000 nM, 3 h) and mouse GP73 (WT), the GP73 CRAC domain deletion mutant (∆CRAC) and the CARC Phe90/CRAC Tyr99 double mutant of mouse GP73 (F90I-Y99I, DM) by MST.
Cholesterol (Water Soluble) purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 May 26;24(1):151. [Abstract]
Titration curves showing changes in the intrinsic fluorescence of WT, Y99I, F90I-Y99I (DM), or scrambled peptides (5 µM) in the presence of increasing concentrations of Cholesterol (0-140 μM).
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Nat Nanotechnol
Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase. [Abstract]2021 Oct;16(10):1150-1160. PMID: 34354264 -
Cell Metab
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury. [Abstract]2024 Nov 5;36(11):2402-2418.e10. PMID: 39389061 -
Immunity
Modulation of the mevalonate pathway by TCR engagement regulates T follicular helper cell generation in homeostasis and autoimmunity. [Abstract]2026 May 13:S1074-7613(26)00171-8. PMID: 42134327 -
Immunity
25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages. [Abstract]2024 May 14;57(5):1087-1104.e7. PMID: 38640930 -
Cancer Commun (Lond)
Lipid metabolism reprograming by SREBP1-PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy. [Abstract]2025 Aug;45(8):1010-1037. PMID: 40439109 -
Nat Biomed Eng
Potent prophylactic cancer vaccines harnessing surface antigens shared by tumour cells and induced pluripotent stem cells. [Abstract]2025 Feb;9(2):215-233. PMID: 39730914 -
Nat Aging
2025 Aug 26. PMID: 40858817 -
Cell Host Microbe
2025 Dec 30:S1931-3128(25)00521-9. PMID: 41475336 -
Nat Commun
Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1. [Abstract]2024 Jan 2;15(1):162. PMID: 38167417
Cholesterol (Water Soluble) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jan 2;15(1):162. [Abstract]
Detection of the exogenous cholesterol activity in SARS2 infection. Indicated Caco2 cells were infected with SARS2-Spseudoviruses and treated with cholesterol (0-200 μg/mL) at indicated concentrations. After 48 hours, viral infection was determined by measuring the intracellular luciferase activity. RLU, relative light unit.
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Exp Mol Med
Cholesterol biosynthesis induced by radiotherapy inhibits cGAS-STING activation and contributes to colorectal cancer treatment resistance. [Abstract]2025 May;57(5):1089-1105. PMID: 40355720 -
Redox Biol
Dysregulated lipids homeostasis disrupts CHAC1-mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer. [Abstract]2025 Jul:84:103693. PMID: 40460553 -
Redox Biol
Accumulated cholesterol protects tumours from elevated lipid peroxidation in the microenvironment. [Abstract]2023 Jun:62:102678. PMID: 36940607 -
Nat Chem Biol
2022 Nov;18(11):1196-1203. PMID: 35982227 -
J Nanobiotechnology
Targeted delivery and ROS-responsive release of Resolvin D1 by platelet chimeric liposome ameliorates myocardial ischemia-reperfusion injury. [Abstract]2022 Oct 20;20(1):454. PMID: 36266658 -
Theranostics
ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3. [Abstract]2021 Jan 1;11(2):841-860. PMID: 33391508 -
Adv Sci (Weinh)
Targeting the HSPA8-CMA-ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer. [Abstract]2026 Jun 19:e76165. PMID: 42318659 -
Adv Sci (Weinh)
An Insulin-Exosome-TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer. [Abstract]2026 Apr;13(24):e15606. PMID: 41709860 -
Adv Sci (Weinh)
Brachyury-Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment. [Abstract]2025 Sep;12(34):e04195. PMID: 40539715
Cholesterol (Water Soluble) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep;12(34):e04195. [Abstract]
Dil staining of GF and BLNP （the formulation (50:38.5:10:1.5) included ionizable lipids (D‐Lin‐MC3‐DMA), Cholesterol, DSPC, and DMG‐PEG2000‐NH2, which were homogeneously mixed in the ethanol phase (12 mM)）@GF microspheres (scale bar = 50 µm).
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Adv Sci (Weinh)
CircUGP2 Suppresses Intrahepatic Cholangiocarcinoma Progression via p53 Signaling Through Interacting With PURB to Regulate ADGRB1 Transcription and Sponging miR-3191-5p. [Abstract]2024 Oct;11(38):e2402329. PMID: 39120980 -
Adv Sci (Weinh)
Granulosa Cell-Layer Stiffening Prevents Escape of Mural Granulosa Cells from the Post-Ovulatory Follicle. [Abstract]2024 Sep;11(33):e2403640. PMID: 38946588 -
Adv Sci (Weinh)
Targeting Squalene Epoxidase Confers Metabolic Vulnerability and Overcomes Chemoresistance in HNSCC. [Abstract]2023 Sep;10(27):e2206878. PMID: 37490552
Cholesterol (Water Soluble) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Sep;10(27):e2206878. [Abstract]
Effects of cholesterol repletion (20 μg/mL; 4 days) on colony formation potential in SCC-1cisR and SCC-23cisR cells with SQLE depletion in the presence of cisplatin (n = 4) were assessed.
Cholesterol (Water Soluble) purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Sep;10(27):e2206878. [Abstract]
SCC-1cisR and SCC-23cisR cells transfected with siCTRL or siSQLE were incubated in medium with or without 20 μg/mL Cholesterol for 24 h.
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Cell Rep Med
Synthetic cleavage-resistant TREM2 boosts macrophage efferocytosis to treat inflammatory diseases. [Abstract]2026 Feb 17;7(2):102580. PMID: 41616764 -
Cell Rep Med
Synergistic mechanical and therapeutic modulation of engineered tumor cell-derived microparticles for enhanced cancer treatment. [Abstract]2026 Feb 17;7(2):102591. PMID: 41666924 -
J Control Release
Antimicrobial peptide-derived lipid nanoparticles enable lung-targeted mRNA therapy for multidrug-resistant bacterial pneumonia. [Abstract]2026 May 23:396:115047. PMID: 42178062 -
J Control Release
Impact of ionizable lipid source on quality and stability of siRNA-loaded lipid nanoparticles. [Abstract]2026 Mar 14:114825. PMID: 41839265 -
J Control Release
Functional lipid nanoparticles for safe delivery of macromolecular antibiotics to gram-negative bacteria. [Abstract]2025 Aug 10:384:113907. PMID: 40451556 -
Phytomedicine
Disruption of cholesterol homeostasis triggers NLRP3-cGAS-STING axis-dependent hepatic fibrosis and honokiol intervention effects. [Abstract]2025 Jul 25:143:156904. PMID: 40449452 -
Phytomedicine
Diosgenin as a substitute for cholesterol alleviates NAFLD by affecting CYP7A1 and NPC1L1-related pathway. [Abstract]2024 Mar:125:155299. PMID: 38301301 -
Adv Healthc Mater
Liposomal Quercetin-Loaded Biomimetic Scaffolds Manage Mechanical Overload in Maxillofacial Regeneration by Stabilizing the β-Actin/YAP Mechanosensing Axis. [Abstract]2026 Jun;15(22):e05818. PMID: 42027072 -
Mater Today Bio
Ultrasound-triggered dissolving microneedle platform for cGAS-STING-mediated precision immunotherapy of melanoma. [Abstract]2026 Mar 2:37:102990. PMID: 41815866 -
Adv Healthc Mater
An Injectable Liposome-Hydrogel Composite for Targeted Delivery of a Non-Lactylated Peptide to Rebalance Bone Metabolism in Hyperlipidemia. [Abstract]2026 Feb 21:e05684. PMID: 41721628 -
Cell Death Discov
Inhibition of lanosterol synthase linking with MAPK/JNK signaling pathway suppresses endometrial cancer. [Abstract]2025 Feb 8;11(1):55. PMID: 39922821 -
Cell Death Discov
Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial apoptosis in diabetic wound healing. [Abstract]2024 May 29;10(1):263. PMID: 38811564 -
Nat Struct Mol Biol
2025 May;32(5):896-904. PMID: 39824976 -
Sci China Life Sci
2022 Feb;65(2):341-361. PMID: 34047913 -
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Int J Nanomedicine
Intraperitoneal Co-Delivery of Claudin18.2×41BB and EpCAM×CD3 Bispecific Antibodies via mRNA-LNPs Synergistically Suppresses Gastric Cancer Peritoneal Metastasis Through T Cell Co-Activation. [Abstract]2026 Mar 20:21:577606. PMID: 41884275 -
Int J Nanomedicine
Optimized Lipid Nanoparticle-Mediated mRNA Co-Delivery of SOX5/SOX9 Enables Synergistic Senescence Reversal for Osteoarthritis Therapy. [Abstract]2025 Oct 22:20:12783-12804. PMID: 41146650 -
Small Methods
Cholesterol-Derived Mannosylated Polypeptide-Formed Lipid Nanoparticles for Efficient in Vivo mRNA Delivery. [Abstract]2025 Jun;9(6):e2401712. PMID: 40256901 -
Free Radic Biol Med
25-Hydroxycholesterol inhibits Hantavirus infection by reprogramming cholesterol metabolism. [Abstract]2024 Nov 1:224:232-245. PMID: 39209137 -
EMBO Mol Med
LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis. [Abstract]2024 Aug;16(8):1755-1790. PMID: 39030302 -
ACS Appl Mater Interfaces
Feedback-Amplified Drug Delivery of αPD-L1-Modified Lipoplatin for Chronological Synergy in NSCLC through PD-L1 Upregulation. [Abstract]2025 Oct 8;17(40):55861-55875. PMID: 40997865 -
ACS Appl Mater Interfaces
Size-Controllable and Monodispersed Lipid Nanoparticle Production with High mRNA Delivery Efficiency Using 3D-Printed Ring Micromixers. [Abstract]2024 Sep 4;16(35):46044-46052. PMID: 39103250 -
NPJ Vaccines
A self-amplifying mRNA vaccine expressing PRV gD induces robust immunity against virulent mutants. [Abstract]2025 Aug 14;10(1):193. PMID: 40813770 -
J Ethnopharmacol
Tylophora yunnanensis extract inhibits cholesterol biosynthesis to suppress triple negative breast cancer. [Abstract]2025 May 28:348:119877. PMID: 40287115 -
Biochem Pharmacol
Triptolide induces the secretion of insulin, through which it alleviates the tauopathies of Alzheimer's disease via inhibiting the phosphorylation of tau. [Abstract]2025 Aug 8;242(Pt 3):117223. PMID: 40784568 -
Cell Biosci
2025 Jul 4;15(1):95. PMID: 40615893 -
Cell Mol Life Sci
Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis. [Abstract]2024 Jul 6;81(1):289. PMID: 38970696 -
Life Sci
CKN reduces TLR4-mediated inflammation and cerebral I/R injury by activating the LXRα/ABCA1 pathway in microglia. [Abstract]2025 Jun 1:370:123571. PMID: 40107493 -
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Life Sci
Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma. [Abstract]2023 Aug 15:327:121698. PMID: 37080351 -
Plant J
Unveiling the inequivalent biochemical functions of OsSMO2-1 and OsSMO2-2 in rice phytosterol biosynthesis using a customized sterol standards mixture. [Abstract]2025 Nov;124(3):e70559. PMID: 41194406 -
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Int J Pharm
Development of a proliposomal pretomanid dry powder inhaler as a novel alternative approach for combating pulmonary tuberculosis. [Abstract]2024 Oct 25:664:124608. PMID: 39163929 -
Biomacromolecules
Replacing PEG-Lipid with Amphiphilic Polycarbonates in mRNA-Loaded Lipid Nanoparticles: Impact of Polycarbonate Structure on Physicochemical and Transfection Properties. [Abstract]2025 Jun 9;26(6):3563-3575. PMID: 40347133 -
Commun Biol
SREBF2 enhances lipid metabolism and represses anti-tumor immune responses in cervical cancer by increasing ACAT2. [Abstract]2026 Feb 7;9(1):373. PMID: 41654690 -
Commun Biol
Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization. [Abstract]2024 Nov 9;7(1):1476. PMID: 39521858 -
Respir Res
Activation of LXR signaling ameliorates apoptosis of alveolar epithelial cells in Bronchopulmonary dysplasia. [Abstract]2024 Nov 7;25(1):399. PMID: 39511537 -
Bioorg Chem
Design and synthesis of novel ionizable lipids enables highly efficient mRNA delivery via lipid nanoparticles. [Abstract]2026 Apr:171:109526. PMID: 41621179 -
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Sci Rep
Serum starvation-induced cholesterol reduction increases melanoma cell susceptibility to cytotoxic T lymphocyte killing. [Abstract]2025 May 26;15(1):18364. PMID: 40419522 -
Cell Signal
Activated PARP1/FAK/COL5A1 signaling facilitates the tumorigenesis of cholesterol-resistant ovarian cancer cells through promoting EMT. [Abstract]2024 Dec:124:111419. PMID: 39293744 -
iScience
CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer. [Abstract]2024 Apr 6;27(5):109676. PMID: 38665208 -
Insect Biochem Mol Biol
2026 Mar:188:104499. PMID: 41548698 -
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Nanomedicine
Quantitative analysis of mRNA-lipid nanoparticle stability in human plasma and serum by size-exclusion chromatography coupled with dual-angle light scattering. [Abstract]2024 Jun:58:102745. PMID: 38499167 -
Antiviral Res
Targeting 7-dehydrocholesterol reductase against EV-A71 replication by upregulating interferon response. [Abstract]2023 Jan:209:105497. PMID: 36528172 -
J Pharm Sci
Development of new nanoniosome carriers for vorinostat: Evaluation of anticancer efficacy in vitro. [Abstract]2024 Aug;113(8):2584-2594. PMID: 38801974 -
Viruses
2022 Mar 3;14(3):514. PMID: 35336921 -
Pathol Res Pract
Alendronate-functionalized ZIF-8 nanoplatform for targeted delivery of SHH siRNA and docetaxel to treat prostate cancer bone metastasis. [Abstract]2025 Sep:273:156138. PMID: 40694986 -
Life Sci Alliance
Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis. [Abstract]2022 Jan 4;5(3):e202101256. PMID: 34983824 -
Vet Microbiol
Pseudorabies virus EP0 recruits TECPR2 and CK2 to promote COPII accumulation and viral egress. [Abstract]2026 Jun 17:320:111115. PMID: 42322707 -
Vet Microbiol
The activation of liver X receptors in Madin-Darby bovine kidney cells and mice restricts infection by bovine viral diarrhea virus. [Abstract]2024 Jan:288:109948. PMID: 38113573 -
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Biochem Biophys Res Commun
Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities. [Abstract]2020 Feb 19;522(4):862-868. PMID: 31806372 -
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용액&용해도
H2O : 50 mg/mL (Need ultrasonic)
DMSO : ≥ 33.33 mg/mL
* "≥" means soluble, but saturation unknown.
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 33.33 mg/mL; Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
순도&문서
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Kimitsuki T. Cholesterol influences potassium currents in inner hair cells isolated from guinea pig cochlea. Auris Nasus Larynx. 2017;44(1):46-51. [Content Brief]
[2]. Nguyen TV, et al. Contribution of membrane cholesterol to outer hair cell lateral wall stiffness. Otolaryngol Head Neck Surg. 1998;119(1):14-20. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cholesterol (Water Soluble) Related Classifications
HY-N0322A Related Classifications
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