Methyl-β-cyclodextrin
Based on 106 publication(s) in Google Scholar
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent. Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis. Methyl-β-cyclodextrin blocks cell migrasome formation.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 128446-36-6
- Molecular Weight:1310 (Average)
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Storage:Powder -20°C, 3 years , 4°C, 2 years
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Biological Activity
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Chemical Information
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Solvent & Solubility
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- Purity & Documentation
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Publications Citing Use of MedChemExpress (MCE) Methyl-β-cyclodextrin
More- Nature. 2024 Feb;626(7998):411-418. [Abstract]
- Nature. 2022 Mar;603(7899):159-165. [Abstract]
- Science. 2025 Feb 21;387(6736):892-900. [Abstract]
- Cell. 2026 Apr 2;189(7):1923-1941.e26. [Abstract]
- Mol Cancer. 2025 Jul 19;24(1):199. [Abstract]
- Cell Metab. 2026 May 5;38(5):963-980.e12. [Abstract]
- Cell Metab. 2024 Jun 18:S1550-4131(24)00189-X. [Abstract]
- Adv Mater. 2025 Jan 10:e2415030. [Abstract]
- Adv Mater. 2022 Jul 28;e2204287. [Abstract]
- Nat Biomed Eng. 2024 Nov;8(11):1469-1482. [Abstract]
- Cell Res. 2021 Sep;31(9):980-997. [Abstract]
- Nat Metab. 2022 Oct;4(10):1369-1401. [Abstract]
- Adv Funct Mater. 2025 Aug 3.
- ACS Nano. 2020 Feb 25;14(2):2172-2182. [Abstract]
- Nat Commun. 2025 Dec 12;16(1):11314. [Abstract]
- Nat Commun. 2025 Sep 26;16(1):8522. [Abstract]
- Nat Commun. 2024 Aug 6;15(1):6689. [Abstract]
- Nat Commun. 2021 Jun 9;12(1):3481. [Abstract]
- Cell Death Differ. 2026 Jan 28. [Abstract]
- Acta Pharm Sin B. 2025 Oct;15(10):5431-5443. [Abstract]
- Adv Sci (Weinh). 2025 Sep 3:e02788. [Abstract]
- Adv Sci (Weinh). 2025 Jul 25:e15313. [Abstract]
- Adv Sci (Weinh). 2025 May 14:e2406150. [Abstract]
- Adv Sci (Weinh). 2025 May 14:e2505310. [Abstract]
- Nat Plants. 2025 Sep 12. [Abstract]
- Biomaterials. 2026 Jun:329:123986. [Abstract]
- J Exp Clin Cancer Res. 2023 Nov 23;42(1):315. [Abstract]
- Carbohydr Polym. 2025 Nov 15;368(Pt 1):124067. [Abstract]
- Sci Adv. 2022 Aug 26;8(34):eabq4722. [Abstract]
- Small. 2026 Mar;22(18):e13435. [Abstract]
- Redox Biol. 2025 May:82:103581. [Abstract]
- Redox Biol. 2023 Jun:62:102678. [Abstract]
- J Control Release. 2026 May 10:393:114784. [Abstract]
- J Control Release. 2025 Dec 16:390:114551. [Abstract]
- J Control Release. 2025 Nov 30:389:114488. [Abstract]
- J Control Release. 2025 Aug 14:386:114128. [Abstract]
- J Control Release. 2025 Aug 29:387:114176. [Abstract]
- J Hazard Mater. 2021 Sep 5;417:126092. [Abstract]
- J Exp Med. 2025 Oct 6;222(10):e20242296. [Abstract]
- Biosens Bioelectron. 2025 Jan 25:274:117184. [Abstract]
- Mater Today Bio. 2025 Mar 27:32:101712. [Abstract]
- J Neuroinflammation. 2025 May 21;22(1):134. [Abstract]
- J Neuroinflammation. 2022 Feb 22;19(1):53. [Abstract]
- Acta Biomater. 2025 Jul 1:201:171-186. [Abstract]
- Cell Death Dis. 2025 Jan 14;16(1):17. [Abstract]
- Cell Death Dis. 2024 Sep 29;15(9):695. [Abstract]
- J Pharm Anal. 2025 Jul;15(7):101182. [Abstract]
- Cell Commun Signal. 2023 May 29;21(1):124. [Abstract]
- Int J Biol Macromol. 2026 Jan;339(Pt 2):150021. [Abstract]
- Int J Biol Macromol. 2025 Apr 28;310(Pt 4):143599. [Abstract]
- Int J Biol Macromol. 2022 May 15:207:559-569. [Abstract]
- Acta Pharmacol Sin. 2025 Nov 3. [Abstract]
- Food Chem X. 2025 Sep 16:31:103046. [Abstract]
- Br J Pharmacol. 2025 Feb;182(3):651-669. [Abstract]
- Br J Pharmacol. 2023 Jul;180(14):1878-1896. [Abstract]
- Br J Pharmacol. 2020 Aug;177(15):3473-3488. [Abstract]
- Emerg Microbes Infect. 2022 Dec;11(1):1135-1144. [Abstract]
- Oncogene. 2026 Apr;45(15):1386-1397. [Abstract]
- Environ Pollut. 2026 Feb 1:390:127492. [Abstract]
- Oncogene. 2025 Oct;44(39):3713-3728. [Abstract]
- Cell Death Discov. 2025 Oct 27;11(1):492. [Abstract]
- Cell Rep. 2024 Mar 21;43(4):113980. [Abstract]
- J Med Chem. 2023 Dec 28;66(24):16579-16596. [Abstract]
- Anal Chem. 2026 Feb 10;98(5):3577-3587. [Abstract]
- Lwt-Food Sci Technol. 2024 Mar 5, 115921.
- J Cell Biol. 2025 May 5;224(5):e202405060. [Abstract]
- Cell Biosci. 2025 Jul 4;15(1):95. [Abstract]
- Cell Biol Toxicol. 2025 Feb 7;41(1):40. [Abstract]
- Front Immunol. 2021 Aug 2;12:686846. [Abstract]
- Colloids Surf B Biointerfaces. 2025 Jun 3:254:114847. [Abstract]
- Biochem Pharmacol. 2025 Jun:236:116870. [Abstract]
- Commun Biol. 2022 Nov 14;5(1):1248. [Abstract]
- PLoS Pathog. 2026 Mar 17;22(3):e1014062. [Abstract]
- Int J Mol Sci. 2025 Mar 29;26(7):3172. [Abstract]
- PLoS Pathog. 2022 Jun 13;18(6):e1010620. [Abstract]
- Front Pharmacol. 2023 Jun 26:14:1191692. [Abstract]
- J Med Virol. 2025 Sep;97(9):e70578. [Abstract]
- J Med Virol. 2023 Jan;95(1):e28266. [Abstract]
- Mol Pharm. 2025 Apr 7;22(4):2182-2192. [Abstract]
- Mol Pharm. 2024 Mar 4;21(3):1149-1159. [Abstract]
- Front Cell Dev Biol. 2021 Jul 7;9:687322. [Abstract]
- FEBS J. 2023 Oct;290(19):4695-4711. [Abstract]
- iScience. 2024 Jun 26;27(7):110388. [Abstract]
- Comput Struct Biotechnol J. 2021;19:1933-1943. [Abstract]
- Antiviral Res. 2023 Jan:209:105497. [Abstract]
- J Biol Chem. 2022 Nov;298(11):102511. [Abstract]
- Virol J. 2025 Jun 4;22(1):181. [Abstract]
- ACS Chem Biol. 2018 Nov 16;13(11):3078-3086. [Abstract]
- Cell Signal. 2025 Jul:131:111753. [Abstract]
- Cell Signal. 2024 Sep 16:111419. [Abstract]
- Open Biol. 2023 Oct;13(10):230215. [Abstract]
- Food Chem Toxicol. 2023 Aug:178:113922. [Abstract]
- Viruses. 2021 May 31;13(6):1035. [Abstract]
- Toxicol Appl Pharmacol. 2019 Oct 1:380:114696. [Abstract]
- Life Sci Alliance. 2022 Jan 4;5(3):e202101256. [Abstract]
- Vet Microbiol. 2025 Apr 8:305:110507. [Abstract]
- Virus Res. 2020 Jan 15;276:197806. [Abstract]
- Biochim Biophys Acta Gen Subj. 2023 Mar;1867(3):130300. [Abstract]
- Mutat Res. 2023 Jul-Dec:827:111829. [Abstract]
- Clinical and Translational Discovery. 20 February 2022.
- Cell Biomater. 2026 Mar 19.
- Npj Viruses. 2026 Feb 16;4(1):10. [Abstract]
- bioRxiv. 2025 March 13.
- bioRxiv. 2024 Jun 25:2024.06.24.600521. [Abstract]
- Research Square Preprint. 2024 Apr 22.
- J Biomed Nanotechnol. 2018 Dec 1;14(12):2114-2123. [Abstract]
Customer Validation & Images
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Cell Imaging/Staining
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IF
Biological Activity
Methyl-β-cyclodextrin is extensively used to increase the permeability of cells, and thereby increase the uptake of small molecules such as glucose and nano-particles[4].
Cyclodextrins are a family of cyclic oligosaccharides with a hydrophilic outer surface and a lipophilic central cavity. Cyclodextrins molecules are relatively large with a number of hydrogen donors and acceptors and, thus in general, they do not permeate lipophilic membranes. In the pharmaceutical industry, cyclodextrins have mainly been used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability. Cyclodextrins are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs[4].
Methyl-β-cyclodextrin quickly induces caspase-dependent apoptosis in PEL cells via cholesterol depletion from the plasma membrane. Methyl-β-cyclodextrin inhibits the growth of all PEL cell lines in a dose-dependent manner. The IC50 is 3.33-4.23 mM in each cell line[5].
Methyl-β-cyclodextrin is a highly water soluble cyclic heptasaccharide consisting of a β-glucopyranose unit, has been reported as the most effective agent for the depletion of cholesterol from cells among the various cholesterol-depleting agents[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Studies in both humans and animals have shown that cyclodextrins can be used to improve drug delivery from almost any type of drug formulation. Currently, there are approximately 30 different pharmaceutical products worldwide containing drug/cyclodextrins complexes in the market[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 128446-36-6
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Appearance Solid
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Molecular Weight 1310 (Average)
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Color White to off-white
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SMILES
CO[C@@H]1[C@H](O[R])[C@H](O[R])[C@@H](C)C(CO[R])O1.[7].[R=H or -CH3]
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Synonyms
Methyl-beta-cyclodextrin
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years
Publications (106)
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Journal Impact Factor
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Most Recent
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Nature
2024 Feb;626(7998):411-418. PMID: 38297130 -
Nature
2022 Mar;603(7899):159-165. PMID: 35197629 -
Science
2025 Feb 21;387(6736):892-900. PMID: 39977508 -
Cell
2026 Apr 2;189(7):1923-1941.e26. PMID: 41785850 -
Mol Cancer
CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA. [Abstract]2025 Jul 19;24(1):199. PMID: 40684174 -
Cell Metab
Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages. [Abstract]2026 May 5;38(5):963-980.e12. PMID: 41856104 -
Cell Metab
Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer. [Abstract]2024 Jun 18:S1550-4131(24)00189-X. PMID: 38897198 -
Adv Mater
Self-Sustained Biophotocatalytic Nano-Organelle Reactors with Programmable DNA Switches for Combating Tumor Metastasis. [Abstract]2025 Jan 10:e2415030. PMID: 39797479 -
Adv Mater
A Tetrahedral Framework DNA-Based Bioswitchable miRNA Inhibitor Delivery System: Application to Skin Anti-Aging. [Abstract]2022 Jul 28;e2204287. PMID: 35901292 -
Nat Biomed Eng
In situ formation of biomolecular condensates as intracellular drug reservoirs for augmenting chemotherapy. [Abstract]2024 Nov;8(11):1469-1482. PMID: 39271933 -
Cell Res
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. [Abstract]2021 Sep;31(9):980-997. PMID: 34012073 -
Nat Metab
2022 Oct;4(10):1369-1401. PMID: 36217034 -
Methyl-β-cyclodextrin purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2025 Aug 3.
Typical confocal images of RAW 264.7 cells incubated with 100 μg/mL FITC/M-BSA@PSiNPs for 6 h, in the absence or presence of 50 μmol/L Pitstop 2, 100 μmol/L Methyl-β-cyclodextrin (MβCD), 50 μmol/L amiloride, or 1 μmol/L CytoD (scale bar = 40 μm).
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ACS Nano
Protein@Inorganic Nanodumpling System for High-Loading Protein Delivery with Activatable Fluorescence and Magnetic Resonance Bimodal Imaging Capabilities. [Abstract]2020 Feb 25;14(2):2172-2182. PMID: 31990525 -
Nat Commun
Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain. [Abstract]2025 Dec 12;16(1):11314. PMID: 41387431 -
Nat Commun
Ocular delivery of lipid nanoparticles-formulated mRNA encoding lanosterol synthase ameliorates cataract in rats. [Abstract]2025 Sep 26;16(1):8522. PMID: 41006301 -
Nat Commun
2024 Aug 6;15(1):6689. PMID: 39107321 -
Nat Commun
TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4. [Abstract]2021 Jun 9;12(1):3481. PMID: 34108482 -
Cell Death Differ
TUFT1 stabilizes TGF-β receptor II protein and facilitates activation of hepatic stellate cells into metastasis-promoting myofibroblasts. [Abstract]2026 Jan 28. PMID: 41593321 -
Acta Pharm Sin B
Spatiotemporally delivery of Cas9 ribonucleoprotein/DNAzyme logic systems using near-infrared upconversion nanomachine for precise immunotherapy. [Abstract]2025 Oct;15(10):5431-5443. PMID: 41132842 -
Adv Sci (Weinh)
Physiological pH Transition-Driven Protein Corona Dynamics Regulate Cellular Uptake and Inflammatory Responses of Silica Nanoparticles. [Abstract]2025 Sep 3:e02788. PMID: 40902197 -
Adv Sci (Weinh)
Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca2+ Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium. [Abstract]2025 Jul 25:e15313. PMID: 40709664 -
Adv Sci (Weinh)
Lipid Droplet-Derived Biomimetic Nanocarriers for the Enhancement of Porcine Intermuscular Fat Content. [Abstract]2025 May 14:e2406150. PMID: 40365640 -
Adv Sci (Weinh)
Nanofabricated Bacterial Cell Walls with Intrinsic Peroxidase-Mimicking and Sonodynamic Activities for Cancer Combination Treatment. [Abstract]2025 May 14:e2505310. PMID: 40365750 -
Nat Plants
An apoplastic fungal effector disrupts N-glycosylation of ZmLecRK1, inducing its degradation to suppress disease resistance in maize. [Abstract]2025 Sep 12. PMID: 40940425 -
Biomaterials
Cardiac and skeletal muscle delivery of biotherapeutics with a blood vessel epicardial substance-targeting peptide. [Abstract]2026 Jun:329:123986. PMID: 41506143 -
J Exp Clin Cancer Res
Transcriptomic landscape based on annotated clinical features reveals PLPP2 involvement in lipid raft-mediated proliferation signature of early-stage lung adenocarcinoma. [Abstract]2023 Nov 23;42(1):315. PMID: 37996944 -
Carbohydr Polym
Premna microphylla Turcz pectin-modified diosmetin nanoparticles: A galectin-3 targeting strategy for precise colitis intervention. [Abstract]2025 Nov 15;368(Pt 1):124067. PMID: 40912828 -
Sci Adv
2022 Aug 26;8(34):eabq4722. PMID: 36026448 -
Small
Dynamically Reprograms Mitochondrial Respiration to Augment Cuproptosis in Cancer Therapy. [Abstract]2026 Mar;22(18):e13435. PMID: 41653427 -
Redox Biol
AGR2-mediated cell-cell communication controls the antiviral immune response by promoting the thiol oxidation of TRAF3. [Abstract]2025 May:82:103581. PMID: 40085973 -
Redox Biol
Accumulated cholesterol protects tumours from elevated lipid peroxidation in the microenvironment. [Abstract]2023 Jun:62:102678. PMID: 36940607 -
J Control Release
Intravitreal delivery of LATS1 mRNA by lipid nanoparticles as an effective strategy for uveal melanoma therapy. [Abstract]2026 May 10:393:114784. PMID: 41786044 -
J Control Release
Cyclization and thermal modulation of a β-hairpin peptide for efficient cellular delivery. [Abstract]2025 Dec 16:390:114551. PMID: 41412216 -
J Control Release
Bioswitchable intracellular delivery of small activating RNA by tetrahedral framework nucleic acid: Application to p21-mediated anti-tumor therapy. [Abstract]2025 Nov 30:389:114488. PMID: 41330514 -
J Control Release
Regulated PEGylation of cationic nanogels for enhanced siRNA delivery and orthotopic ovarian tumor therapy. [Abstract]2025 Aug 14:386:114128. PMID: 40818719 -
J Control Release
Enzyme-instructed disassembly of phosphorylated temporin supramolecules enhances doxorubicin synergy for targeted cancer inhibition. [Abstract]2025 Aug 29:387:114176. PMID: 40886776 -
J Hazard Mater
Systematic toxicity evaluation of polystyrene nanoplastics on mice and molecular mechanism investigation about their internalization into Caco-2 cells. [Abstract]2021 Sep 5;417:126092. PMID: 34015712 -
J Exp Med
2025 Oct 6;222(10):e20242296. PMID: 40644312 -
Biosens Bioelectron
Cathepsin B dependent activatable trigger fluorophore (CAT-Fluor) for in situ functional imaging of antibody-drug conjugates. [Abstract]2025 Jan 25:274:117184. PMID: 39879789 -
Mater Today Bio
Metal-organic framework-based delivery systems as nanovaccine for enhancing immunity against porcine circovirus type 2. [Abstract]2025 Mar 27:32:101712. PMID: 40230641 -
J Neuroinflammation
Caveolin-1 negatively regulates the calcitonin receptor-like receptor and neuroinflammation in a female mouse model of migraine. [Abstract]2025 May 21;22(1):134. PMID: 40399967 -
J Neuroinflammation
α-Synuclein-containing erythrocytic extracellular vesicles: essential contributors to hyperactivation of monocytes in Parkinson's disease. [Abstract]2022 Feb 22;19(1):53. PMID: 35193594 -
Acta Biomater
Hydrogel system with growth cone-targeted hydroxyapatite nanorods: Regulating calcium signals for peripheral nerve injury repair. [Abstract]2025 Jul 1:201:171-186. PMID: 40419070 -
Cell Death Dis
2025 Jan 14;16(1):17. PMID: 39809787 -
Cell Death Dis
ACSL4-mediated lipid rafts prevent membrane rupture and inhibit immunogenic cell death in melanoma. [Abstract]2024 Sep 29;15(9):695. PMID: 39343834 -
J Pharm Anal
Effect of cholesterol on distribution, cell uptake, and protein corona of lipid microspheres at sites of cardiovascular inflammatory injury. [Abstract]2025 Jul;15(7):101182. PMID: 40735031 -
Cell Commun Signal
Vitamin D receptor (VDR) on the cell membrane of mouse macrophages participates in the formation of lipopolysaccharide tolerance: mVDR is related to the effect of artesunate to reverse LPS tolerance. [Abstract]2023 May 29;21(1):124. PMID: 37248534 -
Int J Biol Macromol
Grass carp retinoid-related orphan receptor α (gcRORαa) promotes GCRV replication via LDLR-mediated lipid accumulation. [Abstract]2026 Jan;339(Pt 2):150021. PMID: 41485668 -
Int J Biol Macromol
2025 Apr 28;310(Pt 4):143599. PMID: 40306505 -
Int J Biol Macromol
Polyethylenimine-coated PLGA nanoparticles containing Angelica sinensis polysaccharide promote dendritic cells activation and associated molecular mechanisms. [Abstract]2022 May 15:207:559-569. PMID: 35288164 -
Acta Pharmacol Sin
Sino-C, a novel sinomenine derivative, induces cell death by disrupting cholesterol homeostasis in colorectal cancer cells. [Abstract]2025 Nov 3. PMID: 41184618 -
Food Chem X
Preparation, characterization, assembly, and stability of walnut peptide - zinc complexes and its ability to promote zinc transport in Caco-2 cells. [Abstract]2025 Sep 16:31:103046. PMID: 41036460 -
Br J Pharmacol
The activated caveolin-3/μ-opioid receptor complex drives morphine-induced rescue therapy in failing hearts. [Abstract]2025 Feb;182(3):651-669. PMID: 39427683 -
Br J Pharmacol
2023 Jul;180(14):1878-1896. PMID: 36727262 -
Br J Pharmacol
An orally available hypoglycaemic peptide taken up by caveolae transcytosis displays improved hypoglycaemic effects and body weight control in db/db mice. [Abstract]2020 Aug;177(15):3473-3488. PMID: 32293707 -
Emerg Microbes Infect
SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent manner. [Abstract]2022 Dec;11(1):1135-1144. PMID: 35343395 -
Oncogene
The NPC1/USP7/p53 axis regulates cholesterol and promotes the proliferation of hepatocellular carcinoma. [Abstract]2026 Apr;45(15):1386-1397. PMID: 41882104 -
Environ Pollut
Polystyrene nanoplastics promote fish iridovirus replication via inducing inflammatory response, antioxidant damage and enhancing viral entry. [Abstract]2026 Feb 1:390:127492. PMID: 41349949 -
Oncogene
EMC2 promotes triple negative breast cancer growth by protecting FDFT1 from endoplasmic reticulum associated degradation to impair ferroptosis susceptibility. [Abstract]2025 Oct;44(39):3713-3728. PMID: 40931051 -
Cell Death Discov
Amlodipine exerts inhibitory effects against glioma stem cells through degrading EGFR and down-regulating its downstream pro-survival pathways. [Abstract]2025 Oct 27;11(1):492. PMID: 41145413 -
Cell Rep
Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation. [Abstract]2024 Mar 21;43(4):113980. PMID: 38520693 -
J Med Chem
AcGlcAs: A Novel P53-Targeting Arsenical with Potent Cellular Uptake and Cancer Cell Selectivity. [Abstract]2023 Dec 28;66(24):16579-16596. PMID: 38069817 -
Anal Chem
Fluorogenic Peptide-Modulated 2D ZnO/MnO2 Nanosheet Heterostructure Enables Monitoring of Tumor Early Response to Immunotherapy. [Abstract]2026 Feb 10;98(5):3577-3587. PMID: 41603436 -
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J Cell Biol
2025 May 5;224(5):e202405060. PMID: 40136051 -
Cell Biosci
2025 Jul 4;15(1):95. PMID: 40615893 -
Cell Biol Toxicol
2025 Feb 7;41(1):40. PMID: 39920481 -
Front Immunol
Mannose Receptor Mediates the Activation of Chitooligosaccharides on Blunt Snout Bream ( Megalobrama amblycephala) Macrophages. [Abstract]2021 Aug 2;12:686846. PMID: 34408745 -
Colloids Surf B Biointerfaces
A dual-functional mitochondrial probe for melanoma visualization and PI3K/AKT/mTOR-EMT signaling axis-mediated antitumor therapy. [Abstract]2025 Jun 3:254:114847. PMID: 40482387 -
Biochem Pharmacol
Irisin alleviates steroid-induced vascular dysfunction by regulating the αVβ5-c-Abl-Caveolin-1 signaling pathway. [Abstract]2025 Jun:236:116870. PMID: 40086515 -
Commun Biol
2022 Nov 14;5(1):1248. PMID: 36376440 -
PLoS Pathog
LL-37 selectively targets Plasmodium-infected erythrocytes and exhibits antimalarial activity. [Abstract]2026 Mar 17;22(3):e1014062. PMID: 41843625 -
Int J Mol Sci
D-M159 Synergistically Induces Apoptosis in HeLa Cells Through Endoplasmic Reticulum Stress and Mitochondrial Dysfunction. [Abstract]2025 Mar 29;26(7):3172. PMID: 40243937 -
PLoS Pathog
Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids. [Abstract]2022 Jun 13;18(6):e1010620. PMID: 35696443 -
Front Pharmacol
HECT, UBA and WWE domain containing 1 represses cholesterol efflux during CD4+ T cell activation in Sjögren's syndrome. [Abstract]2023 Jun 26:14:1191692. PMID: 37435494 -
J Med Virol
Pexophagy Triggered by Enterovirus 71 Modulates the Production of Pro-Inflammatory Cytokines Through Cholesterol Accumulation in Lysosomes. [Abstract]2025 Sep;97(9):e70578. PMID: 40856297 -
J Med Virol
2023 Jan;95(1):e28266. PMID: 36319186
Methyl-β-cyclodextrin purchased from MedChemExpress. Usage Cited in: J Med Virol. 2023 Jan;95(1):e28266. [Abstract]
Pretreatment with AY9944 (15, 30 µM), U18666A (5, 10 µM), lovastatin (5, 10 µM) and Methyl-β-cyclodextrin (MβCD; 5, 10 mM) for 2 h can all significantly reduce the level of EV-A71 VP1 protein in HCT-8 cell.
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Mol Pharm
2025 Apr 7;22(4):2182-2192. PMID: 40032688 -
Mol Pharm
2024 Mar 4;21(3):1149-1159. PMID: 38288708 -
Front Cell Dev Biol
CD44v6-O-MWNTS-Loaded Gemcitabine and CXCR4 siRNA Improves the Anti-tumor Effectiveness of Ovarian Cancer. [Abstract]2021 Jul 7;9:687322. PMID: 34307366 -
FEBS J
Binding of different hyaluronan to CD44 mediates distinct cell adhesion dynamics under shear flow. [Abstract]2023 Oct;290(19):4695-4711. PMID: 37254632 -
iScience
2024 Jun 26;27(7):110388. PMID: 39092178 -
Comput Struct Biotechnol J
Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification. [Abstract]2021;19:1933-1943. PMID: 33850607 -
Antiviral Res
Targeting 7-dehydrocholesterol reductase against EV-A71 replication by upregulating interferon response. [Abstract]2023 Jan:209:105497. PMID: 36528172 -
J Biol Chem
SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike-mediated cell-to-cell fusion. [Abstract]2022 Nov;298(11):102511. PMID: 36259516 -
Virol J
Bisbenzylisoquinoline alkaloids inhibit influenza virus replication by disrupting endosomal acidification. [Abstract]2025 Jun 4;22(1):181. PMID: 40468427 -
ACS Chem Biol
2018 Nov 16;13(11):3078-3086. PMID: 30272440 -
Cell Signal
Rosuvastatin inhibits carcinogenesis through Ca2+ triggered endoplasmic reticulum stress pathway in pancreatic cancer. [Abstract]2025 Jul:131:111753. PMID: 40107481 -
Cell Signal
Activated PARP1/FAK/COL5A1 signaling facilitates the tumorigenesis of cholesterol-resistant ovarian cancer cells through promoting EMT. [Abstract]2024 Sep 16:111419. PMID: 39293744 -
Open Biol
2023 Oct;13(10):230215. PMID: 37848053 -
Food Chem Toxicol
V-ATPase V0 subunit activation mediates maduramicin-induced methuosis through blocking endolysosomal trafficking in vitro and in vivo. [Abstract]2023 Aug:178:113922. PMID: 37394175 -
Viruses
Bovine Parainfluenza Virus Type 3 (BPIV3) Enters HeLa Cells via Clathrin-Mediated Endocytosis in a Cholesterol- and Dynamin-Dependent Manner. [Abstract]2021 May 31;13(6):1035. PMID: 34072688 -
Toxicol Appl Pharmacol
The involvement of lipid raft pathway in suppression of TGFβ-mediated metastasis by tolfenamic acid in hepatocellular carcinoma cells. [Abstract]2019 Oct 1:380:114696. PMID: 31381904 -
Life Sci Alliance
Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis. [Abstract]2022 Jan 4;5(3):e202101256. PMID: 34983824 -
Vet Microbiol
Cholesterol-dependent Nsp5-endosomes co-trafficking to lysosomes facilitates porcine reproductive and respiratory syndrome virus replication by activating autophagy. [Abstract]2025 Apr 8:305:110507. PMID: 40215803 -
Virus Res
Muscovy duck reovirus enters susceptible cells via a caveolae-mediated endocytosis-like pathway. [Abstract]2020 Jan 15;276:197806. PMID: 31704247 -
Biochim Biophys Acta Gen Subj
An integrative method for evaluating the biological effects of nanoparticle-protein corona. [Abstract]2023 Mar;1867(3):130300. PMID: 36577488 -
Mutat Res
Downregulated CAV-1 in mouse spinal cord may alleviate bone cancer pain by inhibiting the ERK/CREB pathway. [Abstract]2023 Jul-Dec:827:111829. PMID: 37418818 -
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Npj Viruses
STAT1 signaling controls cholesterol metabolism in epithelial cells and RSV-induced syncytia formation. [Abstract]2026 Feb 16;4(1):10. PMID: 41699197 -
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bioRxiv
Pseudomonas aeruginosa impairs mitochondrial function and metabolism during infection of corneal epithelial cells. [Abstract]2024 Jun 25:2024.06.24.600521. PMID: 38979356 -
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J Biomed Nanotechnol
Synthesis, Characterization, and Biological Study of Carboxyl- and Amino-Rich g-C₃N₄ Nanosheets by Different Processing Routes. [Abstract]2018 Dec 1;14(12):2114-2123. PMID: 30305218
Solvent & Solubility
DMSO : ≥ 100 mg/mL
H2O : ≥ 50 mg/mL
* "≥" means soluble, but saturation unknown.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Protocol
PEL cells are incubated in triplicate in a 96-well microculture plate in the presence of different concentrations of methyl-β-cyclodextrin (0-10 mM) in a final volume of 0.1 mL for 24 h at 37°C. Subsequently, MTT (0.5 mg/mL final concentration) is added to each well. After 3 h of additional incubation, 100 μL of a 0.04 N HCl is added to dissolve the crystals. Absorption values at 570 nm are determined[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Mice: Female NRJ mice are intraperitoneally inoculated with BCBL-1 cells suspended in PBS. The mice are then treated with intraperitoneal injections of PBS or methyl-β-cyclodextrin (500 mg/kg per day). Tumor burdens are evaluated by measuring body weights and ascites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Mundhara N, et al. Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents. Sci Rep. 2019 May 21;9(1):7638. [Content Brief]
[2]. Rodal SK, et al. Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell. 1999;10(4):961-974. [Content Brief]
[3]. Yuwei Huang, et al. Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains. Nat Cell Biol. 2019 Aug;21(8):991-1002. [Content Brief]
[4]. Chen X, et al. Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor. J Biol Chem. 2002 Dec 20;277(51):49631-7. [Content Brief]
[5]. Gotoh K, et al. The antitumor effects of methyl-β-cyclodextrin against primary effusion lymphoma via the depletion of cholesterol from lipid rafts. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):285-9. [Content Brief]
[6]. Tiwari G, et al. Cyclodextrins in delivery systems: Applications. J Pharm Bioallied Sci. 2010 Apr;2(2):72-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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