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  3. ALC-0315

ALC-0315 

Cat. No.: HY-138170 Purity: ≥98.0%
Handling Instructions

ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.

For research use only. We do not sell to patients.

ALC-0315 Chemical Structure

ALC-0315 Chemical Structure

CAS No. : 2036272-55-4

Size Price Stock Quantity
25 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg USD 360 In-stock
Estimated Time of Arrival: December 31
100 mg USD 620 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine[1].

In Vitro

ALC-0315 is used to form lipid nanoparticle for the research of vaccination[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

766.27

Formula

C₄₈H₉₅NO₅

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (130.50 mM; Need ultrasonic)

DMSO : 100 mg/mL (130.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3050 mL 6.5251 mL 13.0502 mL
5 mM 0.2610 mL 1.3050 mL 2.6100 mL
10 mM 0.1305 mL 0.6525 mL 1.3050 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.26 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (3.26 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.26 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
ALC-0315
Cat. No.:
HY-138170
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