1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. nAChR
    GABA Receptor
    Potassium Channel
    Endogenous Metabolite
  3. Cholesterol myristate

Cholesterol myristate (Synonyms: Cholesteryl myristate; Cholesteryl tetradecanoate)

Cat. No.: HY-N2338 Purity: >98.0%
Handling Instructions

Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel.

For research use only. We do not sell to patients.

Cholesterol myristate Chemical Structure

Cholesterol myristate Chemical Structure

CAS No. : 1989-52-2

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Based on 1 publication(s) in Google Scholar

Other Forms of Cholesterol myristate:

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Description

Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate[1]. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

597.01

Formula

C₄₁H₇₂O₂

CAS No.

1989-52-2

SMILES

C[[email protected]@]12[[email protected]]3([H])[[email protected]](CC=C1C[[email protected]@H](OC(CCCCCCCCCCCCC)=O)CC2)([H])[[email protected]@]4([H])[[email protected]@](C)([[email protected]]([[email protected]](C)CCCC(C)C)([H])CC4)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 3.33 mg/mL (5.58 mM; Need ultrasonic)

DMSO : 1 mg/mL (1.68 mM; ultrasonic and warming and heat to 80°C)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6750 mL 8.3751 mL 16.7501 mL
5 mM 0.3350 mL 1.6750 mL 3.3500 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

MSCs are cultured with or without serum in 96-well plates and treated with cholesterol myristate in various concentrations (0, 30 and 300 μg/mL) for 3 days. Each sample is repeated in five independent wells and is incubated for 72 h. After incubation, 20 μL MTT (5 mg/mL) is added and the culture is incubated for a further 4 h. The culture medium is discarded and replaced with 150 μL DMSO. The absorbance at 490nm is measured[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

Cholesterol myristateCholesteryl myristate Cholesteryl tetradecanoatenAChRGABA ReceptorPotassium ChannelEndogenous MetaboliteNicotinic acetylcholine receptorsGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorKcsAInhibitorinhibitorinhibit

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Cholesterol myristate
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