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  3. Environmental Pollutants Endogenous Metabolite
  4. Lecithin

Lecithin  (Synonyms: Polyene phosphatidylcholine)

Cat. No.: HY-B2235 Purity: 98.0%
COA
SDS
Handling Instructions Technical Support

Lecithin is regarded as a safe, conventional phospholipid source. Phospholipids are reported to alter the fatty acid composition and microstructure of the membranes in animal cells.

For research use only. We do not sell to patients.

CAS No. : 8002-43-5

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Lecithin:

Lecithin Related Antibodies

Top Publications Citing Use of Products

    Lecithin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 14:e17330.  [Abstract]

    Addition of GPLs (PCs, PEs, LysoPCs, and LysoPAs; each at 10 µg/mL) to EAC cells for 5 days attenuated the inhibitory effect of TRIM15 knockdown or FOXRED1 overexpression on cell proliferation.

    Lecithin purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2024 Feb, 113, 106041.

    We measured the body weight of mice weekly and the food intake daily for each group. Compared with the control group, the body weight in NAFLD group was obviously increased after 8 and 10 weeks of HFD. However, after 4 weeks of treatment with Eri, the body weight of mice in the Eri-L and Eri-H groups exhibited a significant reduction; however, no notable decrease was observed in the Lecithin (PPC, 150 mg/kg, oral, daily) group. After 6 weeks of Lecithin and Eri treatment, the body weight of mice in the Lecithin, Eri-L, and Eri-H groups was significantly lower than that of mice in the NAFLD group.

    Lecithin purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2024 Feb, 113, 106041.

    Compared with that in the NAFLD group, after 4 or 6 weeks of Eri intervention, the food intake in the Lecithin (PPC, 150 mg/kg, oral, daily), Eri-L and Eri-H groups was significantly decreased.

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Lecithin is regarded as a safe, conventional phospholipid source. Phospholipids are reported to alter the fatty acid composition and microstructure of the membranes in animal cells.

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vitro

    After culturing in MRS broth with 0.2 to 1.0% soy Lecithin, the survival rate of harvested cells increases significantly (P<0.05) in the 0.3% bile challenge compare with the no added soy Lecithin group. The cells incubated with 0.6% soy Lecithin are able to grow in an MRS broth with a higher bile salt content. The cell surface hydrophobicity is enhanced and the membrane integrity in the bile challenge increases after culturing with soy Lecithin. A shift in the fatty acid composition is also observed, illustrating the cell membrane changes in the soy Lecithin culture[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Lecithin Related Antibodies
    Clinical Trial
    CAS No.
    Appearance

    Solid

    Color

    Light brown to yellow

    SMILES

    O=P(OCC[N+](C)(C)C)([O-])OC[C@@H](COC([R])=O)OC([R'])=O.[R,R'=fatty acid residues]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    Ethanol : < 1 mg/mL (insoluble)

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 0.5 mg/mL; Clear solution

      This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 0.5 mg/mL; Clear solution

      This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 98.0%

    SDS (647 KB)

    COA (250 KB) HNMR (241 KB)

    Handling Instructions (2659 KB)
    References
    Cell Assay
    [1]

    MRS broths are supplemented with soy Lecithin concentrations of 0, 0.2, 0.4, 0.6, 0.8 and 1.0%. Each broth is inoculated with a tested strain culture (2%, v/v) and anaerobically incubated at 37°C for 20 h. After incubation, the bacterium cells are harvested by centrifugation at 8000 g for 10 min at 4°C and washed twice in PBS (pH 6.5) plus ethanol (5%, v/v). Strain bile resistance is assessed. The numbers of viable cells are counted by the pouring plate method, and each batch is tested three times[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References
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    Lecithin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Lecithin8002-43-5Polyene phosphatidylcholineEnvironmental PollutantsEndogenous MetaboliteEnvironmental ContaminantsInhibitorinhibitorinhibit

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