2. Immunology/Inflammation MAPK/ERK Pathway Stem Cell/Wnt Apoptosis
  3. Interleukin Related p38 MAPK ERK Apoptosis
  4. Lysophosphatidylcholines

Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis.

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Lysophosphatidylcholines Chemical Structure

Lysophosphatidylcholines Chemical Structure

CAS No. : 9008-30-4

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Based on 1 publication(s) in Google Scholar

Lysophosphatidylcholines Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Lysophosphatidylcholines

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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ERK ERK1 ERK2 ERK5 ERK8

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Description

Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis[1][2][3][4].

IC50 & Target

IL-1β

 

ERK1

 

ERK2

 

In Vitro

Lysophosphatidylcholine (3-100 μM, 24 h) reduced HUVEC viability[1].
Lysophosphatidylcholines (12.5μM, 4 h) upregulates gene expression of IL-1β in human peripheral blood monocytes[2].
Lysophosphatidylcholines (75μM, 24 h) induces apoptosis in HUVEC through a p38-mitogen-activated protein kinase-dependent mechanism[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lysophosphatidylcholines Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HUVEC
Concentration: 3 μM, 10μM, 30 μM, 100 μM
Incubation Time: 24 h
Result: Reduced HUVEC viability in a concentration-dependent manner.

Western Blot Analysis[3]

Cell Line: HUVEC
Concentration: 75 μM
Incubation Time: 24 h
Result: Showed both ERK1/2 and p38-MAPK phosphorylation.
In Vivo

Lysophosphatidylcholines (0.1-20 mg/kg, Oral, single dose) protects against sepsis-induced lethality on albino ICR mice[4].
Lysophosphatidylcholines (0.1-20 mg/kg, Oral, single dose) enhances bacterial clearance, blocks cecal ligation and puncture (CLP)-induced neutrophil deactivation and increases bactericidal activity of neutrophils[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Albino ICR mice [4]
Dosage: 0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg
Administration: Oral
Result: Provided significant protection against cecal ligation and puncture (CLP)-induced lethality at a dose of 1 mg/kg.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Lysophosphatidylcholines]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : 25 mg/mL (Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

H2O : < 0.1 mg/mL (insoluble)

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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (241 KB)

Handling Instructions (2659 KB)
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Lysophosphatidylcholines Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lysophosphatidylcholines9008-30-4Interleukin Relatedp38 MAPKERKApoptosisILExtracellular signal regulated kinaseshuman peripheral blood monocytesHUVECAlbino ICR miceInhibitorinhibitorinhibit

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