Lysophosphatidylcholines

Name: Lysophosphatidylcholines
Brand: MedChemExpress
SKU: HY-139414
Rating: 5.0 (6 reviews)

Cat. No.: HY-139414 Purity: 99.9%: Data Sheet
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Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis.

For research use only. We do not sell to patients.

CAS No. : 9008-30-4

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Customer Review

Based on 6 publication(s) in Google Scholar

6 Publications Citing Use of MCE Lysophosphatidylcholines

IHC

In Vivo Efficacy Study

Cell Proliferation/Viability Assay

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 14:e17330. [Abstract]; Addition of GPLs (PCs, PEs, LysoPCs, and LysoPAs; each at 10 µg/mL) to EAC cells for 5 days attenuated the inhibitory effect of TRIM15 knockdown or FOXRED1 overexpression on cell proliferation.

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]; LPC (1 µL of 1% solution, single round-window administration) induced decreased MBP expression and an increase in F4/80-positive cells, indicating demyelination of spiral ganglion neurons (SGNs).

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]; In the cochleae of mice treated with LPC (1 µL of 1% solution, single round-window administration), MBP was co-localized with F4/80-labeled RCMs in both APOE3 and APOE4 mice; however, APOE4 mice exhibited a lower proportion of MBP-positive RCMs with reduced MBP fluorescence intensity.

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]; Western blot analysis of N-GSDMD, cleaved caspase-11, pro-caspase-11, and β-actin in peripheral blood monocytes (left) and peritoneal macrophages (right) from LPS and CLP model mice following treatment with 150 μg A box, 10 mg/kg LPC, or 50 mg/kg DSF. All experiments were performed at least three times. CLP, cecum ligation and puncture; DSF, disulfiram; LPC, lysophosphatidylcholine; LPS, lipopolysaccharide.

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: J Infect Dis. 2024 Aug 16;230(2):298-308. [Abstract]; Survival curves of LPS (left) and CLP (right) model mice after treatment with 50 mg/kg VX-765 or 10 mg/kg LPC (n = 10). CLP + LPC vs. CLP, **P < 0.01; LPS + LPC vs. LPS, **P < 0.01. All data were collected from at least three independent experiments. CLP, cecum ligation and puncture; LPC, lysophosphatidylcholine; LPS, lipopolysaccharide.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IL-1β

ERK1

ERK2

In Vitro

Lysophosphatidylcholine (3-100 μM, 24 h) reduced HUVEC viability^[1].
Lysophosphatidylcholines (12.5μM, 4 h) upregulates gene expression of IL-1β in human peripheral blood monocytes^[2].
Lysophosphatidylcholines (75μM, 24 h) induces apoptosis in HUVEC through a p38-mitogen-activated protein kinase-dependent mechanism^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	HUVEC
Concentration:	3 μM, 10μM, 30 μM, 100 μM
Incubation Time:	24 h
Result:	Reduced HUVEC viability in a concentration-dependent manner.

Western Blot Analysis^[3]

Cell Line:	HUVEC
Concentration:	75 μM
Incubation Time:	24 h
Result:	Showed both ERK1/2 and p38-MAPK phosphorylation.

In Vivo

Lysophosphatidylcholines (0.1-20 mg/kg, Oral, single dose) protects against sepsis-induced lethality on albino ICR mice^[4].
Lysophosphatidylcholines (0.1-20 mg/kg, Oral, single dose) enhances bacterial clearance, blocks cecal ligation and puncture (CLP)-induced neutrophil deactivation and increases bactericidal activity of neutrophils^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Albino ICR mice ^[4]
Dosage:	0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg
Administration:	Oral
Result:	Provided significant protection against cecal ligation and puncture (CLP)-induced lethality at a dose of 1 mg/kg.

CAS No.

9008-30-4

Appearance

Solid

Color

White to off-white

SMILES

[Lysophosphatidylcholines]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (Need ultrasonic)

Methanol : 25 mg/mL (Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.9%

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Data Sheet (272 KB) SDS (393 KB)

COA (241 KB)

Handling Instructions (2659 KB)

References

[1]. Kim E A, et al. Lysophosphatidylcholine induces endothelial cell injury by nitric oxide production through oxidative stress [J]. The Journal of Maternal-Fetal & Neonatal Medicine, 2009, 22(4): 325-331. [Content Brief]

[2]. Liu-Wu Y, et al. Lysophosphatidylcholine induces the production of IL-1β by human monocytes [J]. Atherosclerosis, 1998, 137(2): 351-357. [Content Brief]

[3]. Takahashi M, et al. Lysophosphatidylcholine induces apoptosis in human endothelial cells through a p38-mitogen-activated protein kinase-dependent mechanism [J]. Atherosclerosis, 2002, 161(2): 387-394. [Content Brief]

[4]. Yan J J, et al. Therapeutic effects of lysophosphatidylcholine in experimental sepsis [J]. Nature medicine, 2004, 10(2): 161-167. [Content Brief]