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Cat. No.: HY-139414

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Lysophosphatidylcholines

7 Cited Publications

Customer Review

Based on 7 publication(s) in Google Scholar

Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis.

For research use only. We do not sell to patients.

Purity: 99.9%
CAS No.: 9008-30-4

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Lysophosphatidylcholines Chemical Structure

CAS No.: 9008-30-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IL-1β

ERK1

ERK2

All Interleukin Related Isoforms :

All p38 MAPK Isoforms :

All ERK Isoforms :

In Vitro

Lysophosphatidylcholine (3-100 μM, 24 h) reduced HUVEC viability^[1].
Lysophosphatidylcholines (12.5μM, 4 h) upregulates gene expression of IL-1β in human peripheral blood monocytes^[2].
Lysophosphatidylcholines (75μM, 24 h) induces apoptosis in HUVEC through a p38-mitogen-activated protein kinase-dependent mechanism^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HUVEC
Concentration:

3 μM, 10μM, 30 μM, 100 μM
Incubation Time:

24 h
Result:

Reduced HUVEC viability in a concentration-dependent manner.

Western Blot Analysis^[3]

Cell Line:

HUVEC
Concentration:

75 μM
Incubation Time:

24 h
Result:

Showed both ERK1/2 and p38-MAPK phosphorylation.

In Vivo

Lysophosphatidylcholines (0.1-20 mg/kg, Oral, single dose) protects against sepsis-induced lethality on albino ICR mice^[4].
Lysophosphatidylcholines (0.1-20 mg/kg, Oral, single dose) enhances bacterial clearance, blocks cecal ligation and puncture (CLP)-induced neutrophil deactivation and increases bactericidal activity of neutrophils^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Albino ICR mice ^[4]
Dosage:

0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg
Administration:

Oral
Result:

Provided significant protection against cecal ligation and puncture (CLP)-induced lethality at a dose of 1 mg/kg.

Chemical Information

CAS No. 9008-30-4
Appearance Solid
Color White to off-white
SMILES

[Lysophosphatidylcholines]
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (7)

All IHCIn Vivo Efficacy StudyIFCell Proliferation/Viability AssayWB

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Journal Impact Factor

Adv Mater

Conformationally Variable Peptides Trap and Detoxify Ox-LDL in Plaques for Attenuating Atherosclerosis in Multiple Species. [Abstract]

2026 Jun;38(33):e21108. PMID: 42116761
J Clin Invest

Leukemia-expanded splenic CD81+ erythroblasts potentiate disease progression in mice by reshaping leukemic cell metabolism. [Abstract]

2025 Dec 15;135(24):e193082. PMID: 41392984
Adv Sci (Weinh)

Obesity-Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis. [Abstract]

2025 Nov 14:e17330. PMID: 41237333

Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 14:e17330. [Abstract]

Addition of GPLs (PCs, PEs, LysoPCs, and LysoPAs; each at 10 µg/mL) to EAC cells for 5 days attenuated the inhibitory effect of TRIM15 knockdown or FOXRED1 overexpression on cell proliferation.
Cell Death Discov

APOE4 impairs macrophage lipophagy and promotes demyelination of spiral ganglion neurons in mouse cochleae. [Abstract]

2025 Apr 21;11(1):190. PMID: 40258814

Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]

LPC (1 µL of 1% solution, single round-window administration) induced decreased MBP expression and an increase in F4/80-positive cells, indicating demyelination of spiral ganglion neurons (SGNs).

Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]

In the cochleae of mice treated with LPC (1 µL of 1% solution, single round-window administration), MBP was co-localized with F4/80-labeled RCMs in both APOE3 and APOE4 mice; however, APOE4 mice exhibited a lower proportion of MBP-positive RCMs with reduced MBP fluorescence intensity.

Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]

Western blot analysis of N-GSDMD, cleaved caspase-11, pro-caspase-11, and β-actin in peripheral blood monocytes (left) and peritoneal macrophages (right) from LPS and CLP model mice following treatment with 150 μg A box, 10 mg/kg LPC, or 50 mg/kg DSF. All experiments were performed at least three times. CLP, cecum ligation and puncture; DSF, disulfiram; LPC, lysophosphatidylcholine; LPS, lipopolysaccharide.
J Infect Dis

Role of Histiocyte-Derived frHMGB1 as a Facilitator in Non-Canonical Pyroptosis of Monocytes/Macrophages in Lethal Sepsis. [Abstract]

2024 Aug 16;230(2):298-308. PMID: 38243905

Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: J Infect Dis. 2024 Aug 16;230(2):298-308. [Abstract]

Survival curves of LPS (left) and CLP (right) model mice after treatment with 50 mg/kg VX-765 or 10 mg/kg LPC (n = 10). CLP + LPC vs. CLP, **P < 0.01; LPS + LPC vs. LPS, **P < 0.01. All data were collected from at least three independent experiments. CLP, cecum ligation and puncture; LPC, lysophosphatidylcholine; LPS, lipopolysaccharide.
Anim Reprod Sci

2026 Jan 12;287:108108.
SSRN

2026 Mar 5.

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (Need ultrasonic)

Methanol : 25 mg/mL (Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

View the Complete Stock Solution Preparation Table

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim E A, et al. Lysophosphatidylcholine induces endothelial cell injury by nitric oxide production through oxidative stress [J]. The Journal of Maternal-Fetal & Neonatal Medicine, 2009, 22(4): 325-331. [Content Brief]

[2]. Liu-Wu Y, et al. Lysophosphatidylcholine induces the production of IL-1β by human monocytes [J]. Atherosclerosis, 1998, 137(2): 351-357. [Content Brief]

[3]. Takahashi M, et al. Lysophosphatidylcholine induces apoptosis in human endothelial cells through a p38-mitogen-activated protein kinase-dependent mechanism [J]. Atherosclerosis, 2002, 161(2): 387-394. [Content Brief]

[4]. Yan J J, et al. Therapeutic effects of lysophosphatidylcholine in experimental sepsis [J]. Nature medicine, 2004, 10(2): 161-167. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Lysophosphatidylcholines

7 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

1/16
1/16

Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 14:e17330. [Abstract]

Customer Validation
Addition of GPLs (PCs, PEs, LysoPCs, and LysoPAs; each at 10 µg/mL) to EAC cells for 5 days attenuated the inhibitory effect of TRIM15 knockdown or FOXRED1 overexpression on cell proliferation.
1/16

Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]

Customer Validation
LPC (1 µL of 1% solution, single round-window administration) induced decreased MBP expression and an increase in F4/80-positive cells, indicating demyelination of spiral ganglion neurons (SGNs).
1/16

Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]

Customer Validation
In the cochleae of mice treated with LPC (1 µL of 1% solution, single round-window administration), MBP was co-localized with F4/80-labeled RCMs in both APOE3 and APOE4 mice; however, APOE4 mice exhibited a lower proportion of MBP-positive RCMs with reduced MBP fluorescence intensity.
1/16

Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]

Customer Validation
Western blot analysis of N-GSDMD, cleaved caspase-11, pro-caspase-11, and β-actin in peripheral blood monocytes (left) and peritoneal macrophages (right) from LPS and CLP model mice following treatment with 150 μg A box, 10 mg/kg LPC, or 50 mg/kg DSF. All experiments were performed at least three times. CLP, cecum ligation and puncture; DSF, disulfiram; LPC, lysophosphatidylcholine; LPS, lipopolysaccharide.
1/16

Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: J Infect Dis. 2024 Aug 16;230(2):298-308. [Abstract]

Customer Validation
Survival curves of LPS (left) and CLP (right) model mice after treatment with 50 mg/kg VX-765 or 10 mg/kg LPC (n = 10). CLP + LPC vs. CLP, **P < 0.01; LPS + LPC vs. LPS, **P < 0.01. All data were collected from at least three independent experiments. CLP, cecum ligation and puncture; LPC, lysophosphatidylcholine; LPS, lipopolysaccharide.

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Lysophosphatidylcholines

Publications Citing Use of MedChemExpress (MCE) Lysophosphatidylcholines

All Interleukin Related Isoforms

All p38 MAPK Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

Publications (7)

Solvent & Solubility

Purity & Documentation

References

Calculators

Help & FAQs

Lysophosphatidylcholines Related Classifications

HY-139414 Related Classifications