A concise synthesis of a promising protein kinase C inhibitor: D-erythro-sphingosine

  • Arch Pharm Res. 2007 Jan;30(1):22-7. doi: 10.1007/BF02977774.
Van-Thoai Pham  1 ,  Jae-Eun Joo ,  Yong-Shou Tian ,  Chang-Young Oh ,  Won-Hun Ham
Affiliations
  • 1. College of Pharmacy, SungKyunKwan University, Suwon 440-746, Korea.
PMID: 17328238 DOI: 10.1007/BF02977774
Abstract

In this study, we explored a convenient and concise route for synthesis of D-erythro-sphingosine 1 from commercially available and cheap L-serine. The key steps are simple preparation of amino ketone 5 from Weinreb amide 3 and high diastereoselective reduction of amino ketone 5 to give the natural erythro-(anti-) isomer.

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