2. Spermine

Spermine  (Synonyms: NSC 268508; Neuridine)

Cat. No.: HY-B1777 Purity: 98.36%
COA Handling Instructions

Molarity Calculator

Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects.

For research use only. We do not sell to patients.

Spermine Chemical Structure

Spermine Chemical Structure

CAS No. : 71-44-3

Size Price Stock Quantity
Solid or liquid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Solid or liquid
100 mg USD 50 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Spermine:

Spermine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects.

In Vitro

Spermine (NSC 268508) at physiologically relevant concentrations inhibits ROS-induced DNA damage, with maximal inhibition observed at 1 to 2 mM. These concentrations are well within the estimates for the physiological concentrations of spermine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Spermine Related Antibodies
Clinical Trial
Molecular Weight

202.34

Formula

C10H26N4
CAS No.
Appearance

<29°C Solid,>29°C Liquid

Color

White to off-white

SMILES

NCCCNCCCCNCCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (617.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9422 mL 24.7109 mL 49.4218 mL
5 mM 0.9884 mL 4.9422 mL 9.8844 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (494.22 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.36%

COA (239 KB) HNMR (237 KB) RP-HPLC (217 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.9422 mL 24.7109 mL 49.4218 mL 123.5544 mL
5 mM 0.9884 mL 4.9422 mL 9.8844 mL 24.7109 mL
10 mM 0.4942 mL 2.4711 mL 4.9422 mL 12.3554 mL
15 mM 0.3295 mL 1.6474 mL 3.2948 mL 8.2370 mL
20 mM 0.2471 mL 1.2355 mL 2.4711 mL 6.1777 mL
25 mM 0.1977 mL 0.9884 mL 1.9769 mL 4.9422 mL
30 mM 0.1647 mL 0.8237 mL 1.6474 mL 4.1185 mL
40 mM 0.1236 mL 0.6178 mL 1.2355 mL 3.0889 mL
50 mM 0.0988 mL 0.4942 mL 0.9884 mL 2.4711 mL
60 mM 0.0824 mL 0.4118 mL 0.8237 mL 2.0592 mL
80 mM 0.0618 mL 0.3089 mL 0.6178 mL 1.5444 mL
100 mM 0.0494 mL 0.2471 mL 0.4942 mL 1.2355 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Spermine71-44-3NSC 268508 NeuridineNSC268508NSC-268508Inhibitorinhibitorinhibit

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