Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity

  • Bioorg Med Chem Lett. 1998 Mar 17;8(6):635-40. doi: 10.1016/s0960-894x(98)00086-9.
S Tomasi  1 ,  M Le Roch ,  J Renault ,  J C Corbel ,  P Uriac ,  B Carboni ,  D Moncoq ,  B Martin ,  J G Delcros
Affiliations
  • 1. Pharmacochimie de Molécules de Synthèse et de Produits Naturels, Faculté de Pharmacie, Rennes, France.
PMID: 9871574 DOI: 10.1016/s0960-894x(98)00086-9
Abstract

A series of N1-monosubstituted putrescine and spermine derivatives was synthesised using a solid phase methodology. We evaluated their cytotoxicity, Calmodulin antagonism and polyamine uptake inhibition, pharmacological properties shared by some antitumoral agents.