71-44-3
71-44-3
Chemical Structure
Spermine
Synonym(s): NSC 268508; Neuridine
- CAS. Nr.: 71-44-3
- Formula:C10H26N4
- Molecular Weight:202.34
IUPAC Name: N1,N1'-(butane-1,4-diyl)bis(propane-1,3-diamine)
InChIKey: PFNFFQXMRSDOHW-UHFFFAOYSA-N
SMILES: NCCCNCCCCNCCCN
Biological Activity: Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine inhibits primary human embryo lung fibroblasts in vitro[1][2][3][4][5][6].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Spermine | 99.79% | Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine inhibits primary human embryo lung fibroblasts in vitro. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Spermine (Standard) | 99.97% | Spermine (Standard) is the analytical standard of Spermine. This product is intended for research and analytical applications. Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Spermine-d20 | 98.47% | Spermine-d20 (NSC 268508-d20) is deuterium labeled Spermine. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Thermospermine | 99.97% | Thermospermine, a structural isomer of Spermine, is synthesized by a thermospermine synthase designated ACAULIS5 (ACL5). Thermospermine suppresses auxin-inducible xylem differentiation in Arabidopsis thaliana. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
N,N'-Bis(3-aminopropyl)oxamide | N,N'-Bis(3-aminopropyl)oxamide is an oxamide-bridged ligand compound typically utilized as a biocuring agent, a chemical building block for bio-based curing agents, and a coordination ligand in organometallic and supramolecular chemistry. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Aminopropylcadaverine | Aminopropylcadaverine is an aminopropyl derivative of cadaverine. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
N,N'-Bis(2-aminoethyl)-1,4-butanediamine | N,N'-Bis (2-aminoethyl)-1,4-butanediamine is a GluR6 (Q) kainate subtype glutamate receptor channel blocker, with a Kd (0) of 41.1 μM for the GluR6 (Q) receptor. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
sym-Homospermidine | sym-Homospermidine is a triamine polyamine and a structural analog of spermidine derived from plants. sym-Homospermidine can be taken up by bacteria and promotes the growth of Spe auxotrophic strains of Escherichia coli without inhibiting the growth of wild-type strains. sym-Homospermidine can be used in Escherichia coli-related research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Spermidine-13C4 hydrochloride | 99.80% | Spermidine-13C4 (hydrochloride) is the 13C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Spermidine (Standard) | 99.65% | Spermidine (Standard) is the analytical standard of Spermidine. This product is intended for research and analytical applications. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Spermine-15N2 | Spermine-15N2 (NSC 268508-15N2) is the 15N-labeled Spermine (HY-B1777). Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Norspermine | 99.94% | Norspermine is a synthetic tetraamine polyamine and a structural analog of Thermospermine (HY-151224), discovered in Thermodesulfobacterium thermophilum and Thermus thermophilus. Norspermine can partially substitute for Thermospermine function during growth and development, and is used in research on tumors, infections, and other conditions. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. U. Bachrach & B. Reches, (1966) Enzymic assay for spermine and spermidine, Analytical Biochemistry, Volume 17, Issue 1, Volume 17, Issue 1, ISSN 0003-2697.
- [2]. Dawson, M., & Dryden, W. F. (1969). The toxicity of spermine and spermidine to cells in culture. Biochemical pharmacology, 18(6), 1307–1313. [Content Brief]
- [3]. Byrd, W. J., et al., (1977). Synthetic polyamines added to cultures containing bovine sera reversibly inhibit in vitro parameters of immunity. Nature, 267(5612), 621–623. [Content Brief]
- [4]. Løvaas, E., & Carlin, G. (1991). Spermine: an anti-oxidant and anti-inflammatory agent. Free radical biology & medicine, 11(5), 455–461. [Content Brief]
- [5]. WANG Jing, et al., (2022) Preliminary Study on Spermine Tetrahydrochloride Inhibition of Platelet Activation[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(3): 315-319.
- [6]. Otsuki, M., et al., (1995). In vivo pharmacological study of spermine-induced neurotoxicity. Neuroscience letters, 196(1-2), 81–84. [Content Brief]
