sym-Homospermidine
sym-Homospermidine is a triamine polyamine and a structural analog of spermidine derived from plants. sym-Homospermidine can be taken up by bacteria and promotes the growth of Spe auxotrophic strains of Escherichia coli without inhibiting the growth of wild-type strains. sym-Homospermidine can be used in Escherichia coli-related research.
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- CAS. Nr.: 4427-76-3
- Formel: C8H21N3
- Molecular Weight:159.27
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| L1210 | IC50 |
100 μM
Compound: 15
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Growth inhibitory activity against L1210 cells (48h)
Growth inhibitory activity against L1210 cells (48h)
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[PMID: 9154970] |
| L1210 | IC50 |
3 μM
Compound: 15
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Growth inhibitory activity against L1210 cells (96h)
Growth inhibitory activity against L1210 cells (96h)
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[PMID: 9154970] |
In Vitro
sym-Homospermidine (0.125-12.5 μg/mL; over at least a ten-fold increase in cell density or after growth to A450 of 0.095 to 0.105) is taken up efficiently by Escherichia coli spermidine auxotrophs DR112 and EWH319 and wild-type strain 3000, stimulates growth of EWH319 with similar efficacy to spermidine at comparable intracellular levels, but is far less effective at stimulating growth of DR112 even at three-fold higher intracellular levels, and does not inhibit growth of wild-type E. coli[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 4427-76-3
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Appearance Solid
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Molecular Weight 159.27
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Formel C8H21N3
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Color White to off-white
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SMILES
NCCCCNCCCCN
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (263 KB)
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SDS (417 KB)
- English - EN (417 KB)
- Français - FR (417 KB)
- Deutsch - DE (417 KB)
- Norwegian - NO (417 KB)
- Español - ES (417 KB)
- Swedish - SV (417 KB)
- Italian - IT (417 KB)
- Korean - KR (417 KB)
- Portuguese - PT (417 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Kim SH, et al. The Essential Role of Spermidine in Growth of Agrobacterium tumefaciens Is Determined by the 1,3-Diaminopropane Moiety. ACS Chem Biol. 2016 Feb 19;11(2):491-9. [Content Brief]
[2]. Linderoth N, et al. Structural specificity of the triamines sym-homospermidine and aminopropylcadaverine in stimulating growth of spermidine auxotrophs of Escherichia coli. Biochemical and biophysical research communications. 1983 Dec 16;117(2):616-22. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
sym-Homospermidine Related Classifications
HY-208041 Related Classifications
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