SYK-IN-14 

SYK-IN-14 is an orally active Syk and ZAP-70 inhibitor with human Syk IC₅₀ of 0.006 μM, human ZAP-70 IC₅₀ of 0.23 μM. SYK-IN-14 functionally inhibits Syk kinase activity in vitro. SYK-IN-14 functionally inhibits ZAP-70 kinase activity in vitro. SYK-IN-14 suppresses passive cutaneous anaphylaxis reaction in Mus musculus mice. SYK-IN-14 suppresses Concanavalin A (HY-P2149)-induced IL-2 production in Mus musculus mice. SYK-IN-14 can be used for the research of allergic disorders and autoimmune diseases^[1].

SYK-IN-14 (9f) potently inhibits purified human Syk kinase domain with an IC₅₀ of 0.006 μM^[1].
SYK-IN-14 inhibits purified human ZAP-70 kinase domain with an IC₅₀ of 0.23 μM^[1].
SYK-IN-14 (24 h) inhibits PHA-induced IL-2 production in human PBMCs with an IC₅₀ of 0.058 μM^[1].
SYK-IN-14 (24 h) inhibits PHA-induced IL-2 production in human whole blood with an IC₅₀ of 0.28 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SYK-IN-14 (9f) (30-100 mg/kg; p.o.) dose-dependently suppresses passive cutaneous anaphylaxis reactions in ICR mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

425.48

C₂₁H₂₇N₇O₃

725237-11-6

NC(C(C1=NC=CN1C(N[C@@H]2[C@@H](CCCC2)N)=N3)=C3NC4=CC(OC)=CC(OC)=C4)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hirabayashi A, et al. Structure–activity relationship studies of imidazo [1, 2-c] pyrimidine derivatives as potent and orally effective Syk family kinases inhibitors[J]. Bioorganic & medicinal chemistry, 2008, 16(20): 9247-9260.