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Cat. No.: HY-183924

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SYK-IN-14

SYK-IN-14 is an orally active Syk and ZAP-70 inhibitor with human Syk IC₅₀ of 0.006 μM, human ZAP-70 IC₅₀ of 0.23 μM. SYK-IN-14 functionally inhibits Syk kinase activity in vitro. SYK-IN-14 functionally inhibits ZAP-70 kinase activity in vitro. SYK-IN-14 suppresses passive cutaneous anaphylaxis reaction in Mus musculus mice. SYK-IN-14 suppresses Concanavalin A (HY-P2149)-induced IL-2 production in Mus musculus mice. SYK-IN-14 can be used for the research of allergic disorders and autoimmune diseases.

For research use only. We do not sell to patients.

CAS No.: 725237-11-6
Formula: C₂₁H₂₇N₇O₃
Molecular Weight:425.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SYK-IN-14 Chemical Structure

CAS No.: 725237-11-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
PBMC	IC₅₀	0.058 μM Compound: 9f	Inhibition of IL2 production in PHA-stimulated human PBMC after 24 hrs by ELISA Inhibition of IL2 production in PHA-stimulated human PBMC after 24 hrs by ELISA	[PMID: 18823784]

In Vitro

SYK-IN-14 (compound 9f) potently inhibits purified human Syk kinase domain with an IC₅₀ of 0.006 μM^[1].
SYK-IN-14 inhibits purified human ZAP-70 kinase domain with an IC₅₀ of 0.23 μM^[1].
SYK-IN-14 (24 h) inhibits PHA-induced IL-2 production in human PBMCs with an IC₅₀ of 0.058 μM^[1].
SYK-IN-14 (24 h) inhibits PHA-induced IL-2 production in human whole blood with an IC₅₀ of 0.28 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SYK-IN-14 (9f) (30-100 mg/kg; p.o.) dose-dependently suppresses passive cutaneous anaphylaxis reactions in ICR mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 725237-11-6
Molecular Weight 425.48
Formula C₂₁H₂₇N₇O₃
SMILES

NC(C(C1=NC=CN1C(N[C@@H]2[C@@H](CCCC2)N)=N3)=C3NC4=CC(OC)=CC(OC)=C4)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hirabayashi A, et al. Structure–activity relationship studies of imidazo [1, 2-c] pyrimidine derivatives as potent and orally effective Syk family kinases inhibitors[J]. Bioorganic & medicinal chemistry, 2008, 16(20): 9247-9260.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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