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ZAP-70

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E1/E2/E3 Enzyme (1) PERK (2) Small Interfering RNA (siRNA) (1) Syk (3) Tyrosinase (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (6)

8

Inhibitors & Agonists

1

Recombinant Proteins

2

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

ZAP-180013 1 Publications Verification	Tyrosinase	Inflammation/Immunology
ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC₅₀ of 1.8 μM. ZAP-180013 inhibits the interaction of *ZAP-70* SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs) .

RDN2150 TFA	Others	Inflammation/Immunology
RDN2150 (Compound 25) TFA is a *ZAP-70* inhibitor (IC₅₀: 14.6 nM). RDN2150 TFA covalently binds to the C346 residue of ZAP-70. RDN2150 TFA inhibits the expression of CD25 and CD69, and inhibits CD4 ⁺ T cell activation. RDN2150 TFA can be used for research of psoriasis .

ZAP70 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ZAP70 Human Pre-designed siRNA Set A contains three designed siRNAs for ZAP70 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ZAP70 Human Pre-designed siRNA Set A ZAP70 Human Pre-designed siRNA Set A

RDN2150	Others	Inflammation/Immunology
RDN2150 (Compound 25) is a *ZAP-70* inhibitor (IC₅₀: 14.6 nM). RDN2150 covalently binds to the C346 residue of ZAP-70. RDN2150 inhibits the expression of CD25 and CD69, and inhibits CD4 ⁺ T cell activation. RDN2150 can be used for research of psoriasis .

PRT062607 P505-15; PRT-2607; BIIB-057	Syk	Inflammation/Immunology
PRT062607(P505-15; PRT-2607; BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.

Cbl-b-IN-16	E1/E2/E3 Enzyme	Cancer
Cbl-b-IN-16 (compound 31) is an orally active Cbl-b inhibtor with IC₅₀ of 30 nM and induces IL-2 production in Hu-T-cells with EC₅₀ of 230 nM. Cbl-b-IN-16 exhibits antitumor activity .

GSK143	Syk PERK	Inflammation/Immunology Cancer
GSK143 is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC₅₀ of 7.5. GSK143 inhibits phosphorylated Erk (pErk: pIC₅₀=7.1) . GSK143 reduces inflammation and prevents recruitment of immune cells in the intestinal muscularis in mice .

GSK143 dihydrochloride	Syk PERK	Inflammation/Immunology Cancer
GSK143 dihydrochloride is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC₅₀ of 7.5. GSK143 dihydrochloride inhibits phosphorylated Erk (pErk: pIC₅₀=7.1) . GSK143 dihydrochloride reduces inflammation and prevents recruitment of immune cells in the intestinal muscularis in mice .

Cat. No.	Compare	Product Name	Species	Source

	ZAP70 Protein, Human (sf9, His, GST) ZAP70; zeta-chain (TCR) associated protein kinase 70kDa; SRK, zeta chain (TCR) associated protein kinase (70 kD); tyrosine-protein kinase ZAP-70; STD; ZAP 70; syk-related tyrosine kinase; 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; zeta-chain associated protein kinase, 70kD; SRK; TZK; ZAP-70; FLJ17670; FLJ17679	Human	Sf9 insect cells

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