2. Metabolic Enzyme/Protease Stem Cell/Wnt MAPK/ERK Pathway Immunology/Inflammation
  3. IFNAR Interleukin Related Tyrosinase ERK
  4. RDN2150

RDN2150 is a ZAP-70 inhibitor with an IC50 of 14.6 nM, and it exhibits selectivity for Syk over other kinases. RDN2150 inhibits signal transduction and activation of T cells/CAR-T cells, reduces the phosphorylation level of Erk1/2, suppresses the induction of CD69 and IL-2, and downregulates phosphotyrosine signaling pathways including hnRNP sites in T cells. RDN2150 can be used for psoriasis-related research.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (RDN2150 TFA) that retains the same biological activity.

For research use only. We do not sell to patients.

RDN2150

RDN2150 Chemical Structure

CAS No. : 2839429-51-3

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RDN2150 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE RDN2150

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ERK ERK1 ERK2 ERK5 ERK8

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Description

RDN2150 is a ZAP-70 inhibitor with an IC50 of 14.6 nM, and it exhibits selectivity for Syk over other kinases. RDN2150 inhibits signal transduction and activation of T cells/CAR-T cells, reduces the phosphorylation level of Erk1/2, suppresses the induction of CD69 and IL-2, and downregulates phosphotyrosine signaling pathways including hnRNP sites in T cells. RDN2150 can be used for psoriasis-related research[1][2].

IC50 & Target

14.6 nM (ZAP-70)[1]
Cellular Effect
Cell Line Type Value Description References
Splenocyte IC50
64 nM
Compound: 25; RDN2150
Immunosuppressive activity in BALB/c mouse Splenocyte assessed as inhibition of concanavalin A induced T-cell proliferation incubated for 48 hrs by [3H]-thymidine incorporation based beta scintillation counter analysis
Immunosuppressive activity in BALB/c mouse Splenocyte assessed as inhibition of concanavalin A induced T-cell proliferation incubated for 48 hrs by [3H]-thymidine incorporation based beta scintillation counter analysis
[PMID: 37594408]
In Vitro

RDN2150 (0.1-10 μM; 3 h) blocks LAT Y220 phosphorylation, disrupts the LAT/SLP76 signalosome, and inhibits downstream Erk1/2 and PLCγ1 activation in Jurkat T cells[2].
RDN2150 (0.1-10 μM; 25 h) inhibits T cell activation markers in Jurkat T cells. In soluble antibody, APC-pMHC/TCR and CD19-CAR/Raji stimulation models, concentrations of 0.1-10 μM reduce CD69 expression and IL-2 secretion, while a concentration of 10 μM completely abrogates soluble antibody-induced CD69 expression[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RDN2150 Related Antibodies

Western Blot Analysis[2]

Cell Line: Jurkat T cells (JOT1 and CD19-CAR Jurkat sublines)
Concentration: 0.1 μM; 1 μM; 10 μM; 100 nM
Incubation Time: 3 h
Result: Reduced basal Erk1/2 phosphorylation at 100 nM.
Impaired phosphorylation of LATY220 across all three stimulation methods at 10 μM.
Left phosphorylation of LckY394 unaffected at any concentration.
Significantly reduced phosphorylation of Erk1T202Y204/Erk2T185Y187 at 1 μM and 10 μM after 2.5 min of stimulation across all activation models.
Significantly enhanced PLCγ1Y783 induction after soluble antibody stimulation at low concentrations (0.1 μM, 1 μM).
In Vivo

RDN2150 (2%; topical; once daily; 7 days) significantly reduces psoriasis-like skin lesions and splenomegaly in an Imiquimod (HY-B0180)-induced mouse model of psoriasis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female, 6-8 weeks old, 18-20 g, Imiquimod-induced psoriasis-like dermatitis)[1]
Dosage: 2% (62.5 mg per application)
Administration: topical; once daily; 7 days
Result: Significantly reduced cumulative psoriasis severity total score (0-12 scale) compared to vehicle/ointment base controls, with statistically significant differences observed from day 2 onward.
Significantly decreased individual scores for scales, skin thickness, and erythema (0-4 scales each) with statistically significant differences from day 2 onward.
Significantly reduced splenomegaly, resulting in a lower spleen index (spleen weight/body weight) compared to the vehicle group.
Molecular Weight

577.03

Formula

C28H29ClN8O4
CAS No.
SMILES

O=C(C1=C(N=C(N2C1=NC=C2)NCC3=CC(NC(C=C)=O)=C(C=C3)Cl)NC4=CC(OC)=C(C=C4)N5CCOCC5)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RDN2150 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RDN21502839429-51-3RDN 2150RDN-2150IFNARInterleukin RelatedTyrosinaseERKInterferon-α/β receptorInterferon-alpha/beta receptor ILExtracellular signal regulated kinasespsoriasisT cellCD25CD69Inhibitorinhibitorinhibit

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