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  4. RDN2150

RDN2150 (Compound 25) is a ZAP-70 inhibitor (IC50: 14.6 nM). RDN2150 covalently binds to the C346 residue of ZAP-70. RDN2150 inhibits the expression of CD25 and CD69, and inhibits CD4+ T cell activation. RDN2150 can be used for research of psoriasis.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (RDN2150 TFA) that retains the same biological activity.

For research use only. We do not sell to patients.

RDN2150 Chemical Structure

RDN2150 Chemical Structure

CAS No. : 2839429-51-3

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Description

RDN2150 (Compound 25) is a ZAP-70 inhibitor (IC50: 14.6 nM). RDN2150 covalently binds to the C346 residue of ZAP-70. RDN2150 inhibits the expression of CD25 and CD69, and inhibits CD4+ T cell activation. RDN2150 can be used for research of psoriasis[1].

IC50 & Target

14.6 nM (ZAP-70)[1]
Molecular Weight

577.03

Formula

C28H29ClN8O4
CAS No.
SMILES

O=C(C1=C(N=C(N2C1=NC=C2)NCC3=CC(NC(C=C)=O)=C(C=C3)Cl)NC4=CC(OC)=C(C=C4)N5CCOCC5)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RDN2150 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RDN21502839429-51-3RDN 2150RDN-2150OtherspsoriasisT cellCD25CD69Inhibitorinhibitorinhibit

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