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  4. RDN2150 TFA

RDN2150 (Compound 25) TFA is a ZAP-70 inhibitor (IC50: 14.6 nM). RDN2150 TFA covalently binds to the C346 residue of ZAP-70. RDN2150 TFA inhibits the expression of CD25 and CD69, and inhibits CD4+ T cell activation. RDN2150 TFA can be used for research of psoriasis.

For research use only. We do not sell to patients.

RDN2150 TFA Chemical Structure

RDN2150 TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 350 In-stock
5 mg USD 780 In-stock
10 mg USD 1250 In-stock
25 mg USD 2460 In-stock
50 mg USD 3950 In-stock
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RDN2150 TFA Related Antibodies

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Description

RDN2150 (Compound 25) TFA is a ZAP-70 inhibitor (IC50: 14.6 nM). RDN2150 TFA covalently binds to the C346 residue of ZAP-70. RDN2150 TFA inhibits the expression of CD25 and CD69, and inhibits CD4+ T cell activation. RDN2150 TFA can be used for research of psoriasis[1].

IC50 & Target

IC50: 14.6 nM (ZAP-70)[1]
Molecular Weight

691.06

Formula

C30H30ClF3N8O6
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=C(N=C(N2C1=NC=C2)NCC3=CC(NC(C=C)=O)=C(C=C3)Cl)NC4=CC(OC)=C(C=C4)N5CCOCC5)N.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (180.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4471 mL 7.2353 mL 14.4705 mL
5 mM 0.2894 mL 1.4471 mL 2.8941 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4471 mL 7.2353 mL 14.4705 mL 36.1763 mL
5 mM 0.2894 mL 1.4471 mL 2.8941 mL 7.2353 mL
10 mM 0.1447 mL 0.7235 mL 1.4471 mL 3.6176 mL
15 mM 0.0965 mL 0.4824 mL 0.9647 mL 2.4118 mL
20 mM 0.0724 mL 0.3618 mL 0.7235 mL 1.8088 mL
25 mM 0.0579 mL 0.2894 mL 0.5788 mL 1.4471 mL
30 mM 0.0482 mL 0.2412 mL 0.4824 mL 1.2059 mL
40 mM 0.0362 mL 0.1809 mL 0.3618 mL 0.9044 mL
50 mM 0.0289 mL 0.1447 mL 0.2894 mL 0.7235 mL
60 mM 0.0241 mL 0.1206 mL 0.2412 mL 0.6029 mL
80 mM 0.0181 mL 0.0904 mL 0.1809 mL 0.4522 mL
100 mM 0.0145 mL 0.0724 mL 0.1447 mL 0.3618 mL
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RDN2150 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RDN2150RDN 2150RDN-2150OtherspsoriasisT cellCD25CD69Inhibitorinhibitorinhibit

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