2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. ZAP-180013

ZAP-180013 

Cat. No.: HY-136179 Purity: 98.56%
COA Handling Instructions

ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC50 of 1.8 μM. ZAP-180013 inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs).

For research use only. We do not sell to patients.

ZAP-180013 Chemical Structure

ZAP-180013 Chemical Structure

CAS No. : 873080-25-2

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Solution
10 mM * 1 mL in DMSO USD 88 In-stock
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ready for reconstitution
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Based on 1 publication(s) in Google Scholar

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Description

ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC50 of 1.8 μM. ZAP-180013 inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs)[1].

IC50 & Target

IC50: 1.8 μM (ZAP-70)[1]
In Vitro

ZAP-70 is a critical molecule in the transduction of T cell antigen receptor signaling and the activation of T cells. Upon activation of the T cell antigen receptor, ZAP-70 is recruited to the intracellular ζ-chains of the T cell receptor, where ZAP-70 is activated and colocalized with its substrates. Inhibitors of ZAP-70 could potentially function as treatments for autoimmune diseases or organ transplantation. ZAP-180013 disrupts the interaction between ZAP-70 and the T cell antigen receptor. The IC50s in both FP and TR-FRET assays for ZAP-180013 are 9.6 μM and 16.841 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

454.33

Appearance

Solid

Formula

C19H17Cl2N3O4S
CAS No.
SMILES

O=C(C1=NC(S(=O)(CC)=O)=NC=C1Cl)N(CC2=CC=C(Cl)C=C2)CC3=CC=CO3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (550.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2010 mL 11.0052 mL 22.0104 mL
5 mM 0.4402 mL 2.2010 mL 4.4021 mL
10 mM 0.2201 mL 1.1005 mL 2.2010 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (4.58 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.58 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.56%

COA (252 KB) HNMR (207 KB) LCMS (112 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

ZAP-180013873080-25-2ZAP180013ZAP 180013TyrosinaseZAP-70T-cellantigentyrosineautoimmuneInhibitorinhibitorinhibit

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